SCOPe 2.05: Domain d1u2za_: 1u2z A:

Lineage for d1u2za_ (1u2z A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (58 families)

5. Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 proteins)

6. Protein Catalytic, N-terminal domain of histone methyltransferase Dot1l [89747] (2 species)
   a non-SET domain nucleosomal histone methyltransferase

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [110667] (1 PDB entry)
   Uniprot Q04089 176-581

8. Domain d1u2za_: 1u2z A: [107626]
   complexed with sah

Details for d1u2za_

PDB Entry: 1u2z, 2.2 Å

PDB Description: Crystal structure of histone K79 methyltransferase Dot1p from yeast

PDB Compounds: (A:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d1u2za_:

Sequence, based on SEQRES records:

>d1u2za_ c.66.1.31 (A:) Catalytic, N-terminal domain of histone methyltransferase Dot1l {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
sstfvdwngpclrlqyplfdieylrsheiysgtpiqsislrtnspqptsltsdndtssvt
taklqsilfsnymeeykvdfkrstaiynpmseigklieysclvflpspyaeqlketilpd
lnasfdnsdtkgfvnainlynkmireiprqriidhletidkiprsfihdflhivytrsih
pqanklkhykafsnyvygellpnflsdvyqqcqlkkgdtfmdlgsgvgncvvqaalecgc
alsfgceimddasdltilqyeelkkrcklygmrlnnvefslkksfvdnnrvaelipqcdv
ilvnnflfdedlnkkvekilqtakvgckiislkslrsltyqinfynvenifnrlkvqryd
lkedsvswthsggeyyistvmedvdeslfspaargrrnrgtpvkyt

Sequence, based on observed residues (ATOM records):

>d1u2za_ c.66.1.31 (A:) Catalytic, N-terminal domain of histone methyltransferase Dot1l {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
sstfvdwngpclrlqyplfdieylrsheiysgtpiqsislrttaklqsilfsnymeeykv
dfkrstaiynpmseigklieysclvflpspyaeqlketilpdlnasfdnsdtkgfvnain
lynkmireiprqriidhletidkiprsfihdflhivytrsihpqanklkhykafsnyvyg
ellpnflsdvyqqcqlkkgdtfmdlgsgvgncvvqaalecgcalsfgceimddasdltil
qyeelkkrcklygmrlnnvefslkksfvdnnrvaelipqcdvilvnnflfdedlnkkvek
ilqtakvgckiislkslrsltyqinfynvenifnrlkvqrydlkedsvswthsggeyyis
tvmedvdeslfsparvkyt

Timeline for d1u2za_:

• d1u2za_ first appeared in SCOP 1.69
  
• d1u2za_ appears in SCOPe 2.04
  
• d1u2za_ appears in SCOPe 2.06
  
• d1u2za_ appears in the current release, SCOPe 2.08