SCOPe 2.08: Domain d1u22a2: 1u22 A:396-760

Lineage for d1u22a2 (1u22 A:396-760)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.22: UROD/MetE-like [51726] (3 families)

5. Family c.1.22.2: Cobalamin-independent methionine synthase [110384] (1 protein)
   Pfam PF01717; duplication; consists of two related domains

6. Protein 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE [110385] (1 species)

7. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [110386] (4 PDB entries)
   Uniprot O50008

8. Domain d1u22a2: 1u22 A:396-760 [107609]
   complexed with hcs, so4, thg, zn

Details for d1u22a2

PDB Entry: 1u22, 2.65 Å

PDB Description: A. thaliana cobalamine independent methionine synthase

PDB Compounds: (A:) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

SCOPe Domain Sequences for d1u22a2:

Sequence, based on SEQRES records:

>d1u22a2 c.1.22.2 (A:396-760) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE {Thale cress (Arabidopsis thaliana) [TaxId: 3702]}
egvqkaaaalkgsdhrratnvsarldaqqkklnlpilptttigsfpqtvelrrvrreyka
kkvseedyvkaikeeikkvvdlqeeldidvlvhgeperndmveyfgeqlsgfaftangwv
qsygsrcvkppviygdvsrpkamtvfwsamaqsmtsrpmkgmltgpvtilnwsfvrndqp
rhetcyqialaikdevedlekggigviqideaalreglplrksehafyldwavhsfritn
cgvqdstqihthmcyshfndiihsiidmdadvitiensrsdekllsvfregvkygagigp
gvydihspripsseeiadrvnkmlavleqnilwvnpdcglktrkytevkpalknmvdaak
lirsq

Sequence, based on observed residues (ATOM records):

>d1u22a2 c.1.22.2 (A:396-760) 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE {Thale cress (Arabidopsis thaliana) [TaxId: 3702]}
egvqkaaaalkgsdhrratnvsarldaqqkklnlpilptttigsfpqtvelredyvkaik
eeikkvvdlqeeldidvlvhgeperndmveyfgeqlsgfaftangwvqsygsrcvkppvi
ygdvsrpkamtvfwsamaqsmtsrpmkgmltgpvtilnwsfvrndqprhetcyqialaik
devedlekggigviqideaalreglplrksehafyldwavhsfritncgvqdstqihthm
cyshfndiihsiidmdadvitiensrsdekllsvfregvkygagigpgvydihspripss
eeiadrvnkmlavleqnilwvnpdcglktrkytevkpalknmvdaaklirsq

Timeline for d1u22a2:

• d1u22a2 first appeared in SCOP 1.69
  
• d1u22a2 appears in SCOPe 2.07