SCOPe 2.08: Domain d1tt5d_: 1tt5 D:

Lineage for d1tt5d_ (1tt5 D:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

4. Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families)
   transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
   the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

5. Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (3 proteins)
   the common fold is elaborated with additional (sub)domains

6. Protein UBA3 [89764] (1 species)
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)

7. Species Human (Homo sapiens) [TaxId:9606] [89765] (12 PDB entries)
   Uniprot Q8TBC4 33-458

8. Domain d1tt5d_: 1tt5 D: [107294]
   Other proteins in same PDB: d1tt5a_, d1tt5b2, d1tt5c_
   complexed with zn
   has additional subdomain(s) that are not in the common domain

Details for d1tt5d_

PDB Entry: 1tt5, 2.6 Å

PDB Description: structure of appbp1-uba3-ubc12n26: a unique e1-e2 interaction required for optimal conjugation of the ubiquitin-like protein nedd8

PDB Compounds: (D:) ubiquitin-activating enzyme E1C isoform 1

SCOPe Domain Sequences for d1tt5d_:

Sequence, based on SEQRES records:

>d1tt5d_ c.111.1.2 (D:) UBA3 {Human (Homo sapiens) [TaxId: 9606]}
wnhvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknlalsgfrqih
vidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiqdfndtfyr
qfhiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgnarvilpgm
taciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvpldgddpeh
iqwifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevfkiatsayi
plnnylvfndvdglytytfeaerkencpacsqlpqniqfspsaklqevldyltnsaslqm
kspaitatlegknrtlylqsvtsieertrpnlsktlkelglvdgqelavadvttpqtvlf
k

Sequence, based on observed residues (ATOM records):

>d1tt5d_ c.111.1.2 (D:) UBA3 {Human (Homo sapiens) [TaxId: 9606]}
wnhvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknlalsgfrqih
vidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiqdfndtfyr
qfhiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgnarvilpgm
taciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvpldgddpeh
iqwifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevfkiatsayi
plnnylvfndvdglytytfeaerkencpacsqlpqniqlqevldyltnsaslqmkspait
atknrtlylqvtsieertrplavadvttpqtvlfk

Timeline for d1tt5d_:

• d1tt5d_ first appeared in SCOP 1.69
  
• d1tt5d_ appears in SCOPe 2.07