SCOPe 2.08: Domain d1tq7.1: 1tq7 A:,B:

Lineage for d1tq7.1 (1tq7 A:,B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (171 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d1tq7.1: 1tq7 A:,B: [107203]
   complexed with 0g6, nag, zn; mutant

Details for d1tq7.1

PDB Entry: 1tq7, 2.4 Å

PDB Description: crystal structure of the anticoagulant thrombin mutant w215a/e217a bound to ppack

PDB Compounds: (A:) Prothrombin, (B:) Prothrombin

SCOPe Domain Sequences for d1tq7.1:

Sequence, based on SEQRES records:

>g1tq7.1 b.47.1.2 (A:,B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
yqtffnprtfgsgeadcglrplfekksledkterellesyidgrXivegsdaeigmspwq
vmlfrkspqellcgaslisdrwvltaahcllyppwdknftendllvrigkhsrtryerni
ekismlekiyihprynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagyk
grvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdeg
krgdacegdsggpfvmkspfnnrwyqmgivsagagcdrdgkygfythvfrlkkwiqkvid
qf

Sequence, based on observed residues (ATOM records):

>g1tq7.1 b.47.1.2 (A:,B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
yqtffnprtfgsgeadcglrplfekksledkterellesyidgrXivegsdaeigmspwq
vmlfrkspqellcgaslisdrwvltaahcllyppwdknftendllvrigkhsrtryerni
ekismlekiyihprynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagyk
grvtgwgnlketkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdac
egdsggpfvmkspfnnrwyqmgivsagagcdrdgkygfythvfrlkkwiqkvidqf

Timeline for d1tq7.1:

• d1tq7.1 first appeared in SCOP 1.69
  
• d1tq7.1 appears in SCOPe 2.07