SCOPe 2.08: Domain d1ti7a_: 1ti7 A:

Lineage for d1ti7a_ (1ti7 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein Negative transcriptional regulator NmrA [69407] (1 species)
   has an UDP-galactose 4-epimerase-like structure but evolved a different function

7. Species Emericella nidulans (Aspergillus nidulans) [TaxId:162425] [69408] (6 PDB entries)
   Uniprot O59919

8. Domain d1ti7a_: 1ti7 A: [106998]
   complexed with cl, gol, k, nap
   has additional subdomain(s) that are not in the common domain

Details for d1ti7a_

PDB Entry: 1ti7, 1.7 Å

PDB Description: crystal structure of nmra, a negative transcriptional regulator, in complex with nadp at 1.7a resolution

PDB Compounds: (A:) nitrogen metabolite repression regulator nmra

SCOPe Domain Sequences for d1ti7a_:

Sequence, based on SEQRES records:

>d1ti7a_ c.2.1.2 (A:) Negative transcriptional regulator NmrA {Emericella nidulans (Aspergillus nidulans) [TaxId: 162425]}
qqkktiavvnatgrqaaslirvaaavghhvraqvhslkgliaeelqaipnvtlfqgplln
nvplmdtlfegahlafinttsqagdeiaigkdladaakragtiqhyiyssmpdhslygpw
pavpmwapkftvenyvrqlglpstfvyagiynnnftslpyplfqmelmpdgtfewhapfd
pdiplpwldaehdvgpallqifkdgpqkwnghrialtfetlspvqvcaafsralnrrvty
vqvpkveikvnipvgyreqleaievvfgehkapyfplpefsrpaagspkglgpangkgag
agmmqgpggvisqrvtdearklwsgwrdmeeyarevfpieeeangldwml

Sequence, based on observed residues (ATOM records):

>d1ti7a_ c.2.1.2 (A:) Negative transcriptional regulator NmrA {Emericella nidulans (Aspergillus nidulans) [TaxId: 162425]}
qqkktiavvnatgrqaaslirvaaavghhvraqvhslkgliaeelqaipnvtlfqgplln
nvplmdtlfegahlafinttsqagdeiaigkdladaakragtiqhyiyssmpdhslygpw
pavpmwapkftvenyvrqlglpstfvyagiynnnftslpyplfqmelmpdgtfewhapfd
pdiplpwldaehdvgpallqifkdgpqkwnghrialtfetlspvqvcaafsralnrrvty
vqvpkveikvnipvgyreqleaievvfgehkapyfplpefpggvisqrvtdearklwsgw
rdmeeyarevfpieeeangldwml

Timeline for d1ti7a_:

• d1ti7a_ first appeared in SCOP 1.69
  
• d1ti7a_ appears in SCOPe 2.07