SCOPe 2.06: Domain d1ta2a_: 1ta2 A:

Lineage for d1ta2a_ (1ta2 A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (170 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d1ta2a_: 1ta2 A: [106730]
   complexed with 176

Details for d1ta2a_

PDB Entry: 1ta2, 2.3 Å

PDB Description: crystal structure of thrombin in complex with compound 1

PDB Compounds: (A:) thrombin

SCOPe Domain Sequences for d1ta2a_:

Sequence, based on SEQRES records:

>d1ta2a_ b.47.1.2 (A:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
dcglrplfekksledkterellesyidgrivegsdaeigmspwqvmlfrkspqellcgas
lisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihpryn
wrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtan
vgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvm
kspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqfg

Sequence, based on observed residues (ATOM records):

>d1ta2a_ b.47.1.2 (A:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
dcglrplfekksledkterellesyiivegsdaeigmspwqvmlfrkspqellcgaslis
drwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwre
nldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlkegqpsvlqv
vnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqm
givswgegcdrdgkygfythvfrlkkwiqkvidqfg

Timeline for d1ta2a_:

• d1ta2a_ first appeared in SCOP 1.69
  
• d1ta2a_ appears in SCOPe 2.05
  
• d1ta2a_ appears in SCOPe 2.07
  
• d1ta2a_ appears in the current release, SCOPe 2.08