SCOPe 2.05: Domain d1t69a_: 1t69 A:

Lineage for d1t69a_ (1t69 A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein Histone deacetylase 8, HDAC8 [110587] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110588] (5 PDB entries)
   Uniprot Q9BY41 13-375 ! Uniprot Q9BY41

8. Domain d1t69a_: 1t69 A: [106554]
   complexed with shh, zn

Details for d1t69a_

PDB Entry: 1t69, 2.91 Å

PDB Description: Crystal Structure of human HDAC8 complexed with SAHA

PDB Compounds: (A:) Histone deacetylase 8

SCOPe Domain Sequences for d1t69a_:

Sequence, based on SEQRES records:

>d1t69a_ c.42.1.2 (A:) Histone deacetylase 8, HDAC8 {Human (Homo sapiens) [TaxId: 9606]}
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckv
ainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsfts
kvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyq
afnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantar
cwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnl
khvv

Sequence, based on observed residues (ATOM records):

>d1t69a_ c.42.1.2 (A:) Histone deacetylase 8, HDAC8 {Human (Homo sapiens) [TaxId: 9606]}
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqpdsieyglgydcpategifdyaaaiggatitaaqclidgmckvainwsg
gwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvs
lhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpka
vvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwtylt
gvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvv

Timeline for d1t69a_:

• d1t69a_ first appeared in SCOP 1.69
  
• d1t69a_ appears in SCOPe 2.04
  
• d1t69a_ appears in SCOPe 2.06
  
• d1t69a_ appears in the current release, SCOPe 2.08