SCOPe 2.08: Domain d1t46a_: 1t46 A:

Lineage for d1t46a_ (1t46 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-KIT receptor [103296] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103297] (18 PDB entries)
   Uniprot P10721 547-935

8. Domain d1t46a_: 1t46 A: [106397]
   complexed with po4, sti

Details for d1t46a_

PDB Entry: 1t46, 1.6 Å

PDB Description: structural basis for the autoinhibition and sti-571 inhibition of c- kit tyrosine kinase

PDB Compounds: (A:) Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

SCOPe Domain Sequences for d1t46a_:

Sequence, based on SEQRES records:

>d1t46a_ d.144.1.7 (A:) c-KIT receptor {Human (Homo sapiens) [TaxId: 9606]}
gnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvavkm
lkpsahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnflrr
krdsficsktspaimeddelaldledllsfsyqvakgmaflaskncihrdlaarnillth
gritkicdfglardikndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwel
fslgsspypgmpvdskfykmikegfrmlspehapaemydimktcwdadplkrptfkqivq
liekqisestn

Sequence, based on observed residues (ATOM records):

>d1t46a_ d.144.1.7 (A:) c-KIT receptor {Human (Homo sapiens) [TaxId: 9606]}
gnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvavkm
lkpsahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnflrr
krdsflaldledllsfsyqvakgmaflaskncihrdlaarnillthgritkicdfglard
ikndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwelfslgsspypgmpvd
skfykmikegfrmlspehapaemydimktcwdadplkrptfkqivqliekqisestn

Timeline for d1t46a_:

• d1t46a_ first appeared in SCOP 1.69
  
• d1t46a_ appears in SCOPe 2.07