SCOP 1.69: Domain d1t40a_: 1t40 A:

Lineage for d1t40a_ (1t40 A:)

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (31 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (1 family)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (15 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (21 PDB entries)

8. Domain d1t40a_: 1t40 A: [106390]

Details for d1t40a_

PDB Entry: 1t40, 1.8 Å

PDB Description: crystal structure of human aldose reductase complexed with nadp and idd552 at ph 5

SCOP Domain Sequences for d1t40a_:

Sequence; same for both SEQRES and ATOM records:

>d1t40a_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens)}
masrlllnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llsctshkdypfheef

Timeline for d1t40a_:

• d1t40a_ is new in SCOP 1.69
  
• d1t40a_ appears in SCOP 1.71
  
• d1t40a_ appears in the current release, SCOPe 2.08