SCOP 1.75: Domain d1t3na2: 1t3n A:27-299

Lineage for d1t3na2 (1t3n A:27-299)

1. Root: SCOP 1.75

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain [100888] (4 proteins)
   contains a distinct 'fingers' domain possibly related to the C-terminal subdomain of hypothetical protein Ta1206 (1qw2)

6. Protein DNA polymerase iota [111295] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [111296] (8 PDB entries)
   Uniprot Q9UNA4

8. Domain d1t3na2: 1t3n A:27-299 [106364]
   Other proteins in same PDB: d1t3na1, d1t3nb1

Details for d1t3na2

PDB Entry: 1t3n, 2.3 Å

PDB Description: structure of the catalytic core of dna polymerase iota in complex with dna and dttp

PDB Compounds: (A:) polymerase (DNA directed) iota

SCOP Domain Sequences for d1t3na2:

Sequence; same for both SEQRES and ATOM records:

>d1t3na2 e.8.1.7 (A:27-299) DNA polymerase iota {Human (Homo sapiens) [TaxId: 9606]}
srvivhvdldcfyaqvemisnpelkdkplgvqqkylvvtcnyearklgvkklmnvrdake
kcpqlvlvngedltryremsykvtelleefspvverlgfdenfvdltemvekrlqqlqsd
elsavtvsghvynnqsinlldvlhirllvgsqiaaemreamynqlgltgcagvasnklla
klvsgvfkpnqqtvllpescqhlihslnhikeipgigyktakclealginsvrdlqtfsp
kilekelgisvaqriqklsfgednspvilsgpp

Timeline for d1t3na2:

• d1t3na2 first appeared in SCOP 1.69
  
• d1t3na2 appears in SCOP 1.73
  
• d1t3na2 appears in SCOPe 2.01
  
• d1t3na2 appears in the current release, SCOPe 2.08