Lineage for d1szca1 (1szc A:1-293)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2107255Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
  4. 2107256Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families) (S)
    binds cofactor molecules in the opposite direction than classical Rossmann fold
  5. 2107522Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 protein domains)
    silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain
  6. 2107546Protein Hst2 [102294] (1 species)
  7. 2107547Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [102295] (5 PDB entries)
    Uniprot P53686 1-293
  8. 2107550Domain d1szca1: 1szc A:1-293 [106149]
    Other proteins in same PDB: d1szca2
    complexed with cl, cna, gol, zn

Details for d1szca1

PDB Entry: 1szc (more details), 1.75 Å

PDB Description: Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases
PDB Compounds: (A:) NAD-dependent deacetylase HST2

SCOPe Domain Sequences for d1szca1:

Sequence, based on SEQRES records: (download)

>d1szca1 c.31.1.5 (A:1-293) Hst2 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
msvstastemsvrkiaahmksnpnakvifmvgagistscgipdfrspgtglyhnlarlkl
pypeavfdvdffqsdplpfytlakelypgnfrpskfhyllklfqdkdvlkrvytqnidtl
erqagvkddliieahgsfahchcigcgkvyppqvfksklaehpikdfvkcdvcgelvkpa
ivffgedlpdsfsetwlndsewlrekittsgkhpqqplvivvgtslavypfaslpeeipr
kvkrvlcnletvgdfkankrptdlivhqysdefaeqlveelgwqedfekilta

Sequence, based on observed residues (ATOM records): (download)

>d1szca1 c.31.1.5 (A:1-293) Hst2 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
msvstastemsvrkiaahmksnpnakvifmvgagistscgipdfrspgtglyhnlarlkl
pypeavfdvdffqsdplpfytlakelypgnfrpskfhyllklfqdkdvlkrvytqnidtl
erqagvkddliieahgsfahchcigcgkvyppqvfksklaehpikdfvkcdvcgelvkpa
ivffgedlpdsfsetwlndsewlrekittqqplvivvgtslavypfaslpeeiprkvkrv
lcnletvgdfkankrptdlivhqysdefaeqlveelgwqedfekilta

SCOPe Domain Coordinates for d1szca1:

Click to download the PDB-style file with coordinates for d1szca1.
(The format of our PDB-style files is described here.)

Timeline for d1szca1: