SCOPe 2.08: Domain d1szca1: 1szc A:1-293

Lineage for d1szca1 (1szc A:1-293)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein Hst2 [102294] (1 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [102295] (5 PDB entries)
   Uniprot P53686 1-293

8. Domain d1szca1: 1szc A:1-293 [106149]
   Other proteins in same PDB: d1szca2
   complexed with cl, cna, gol, zn

Details for d1szca1

PDB Entry: 1szc, 1.75 Å

PDB Description: Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2 histone/protein deacetylases

PDB Compounds: (A:) NAD-dependent deacetylase HST2

SCOPe Domain Sequences for d1szca1:

Sequence, based on SEQRES records:

>d1szca1 c.31.1.5 (A:1-293) Hst2 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
msvstastemsvrkiaahmksnpnakvifmvgagistscgipdfrspgtglyhnlarlkl
pypeavfdvdffqsdplpfytlakelypgnfrpskfhyllklfqdkdvlkrvytqnidtl
erqagvkddliieahgsfahchcigcgkvyppqvfksklaehpikdfvkcdvcgelvkpa
ivffgedlpdsfsetwlndsewlrekittsgkhpqqplvivvgtslavypfaslpeeipr
kvkrvlcnletvgdfkankrptdlivhqysdefaeqlveelgwqedfekilta

Sequence, based on observed residues (ATOM records):

>d1szca1 c.31.1.5 (A:1-293) Hst2 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
msvstastemsvrkiaahmksnpnakvifmvgagistscgipdfrspgtglyhnlarlkl
pypeavfdvdffqsdplpfytlakelypgnfrpskfhyllklfqdkdvlkrvytqnidtl
erqagvkddliieahgsfahchcigcgkvyppqvfksklaehpikdfvkcdvcgelvkpa
ivffgedlpdsfsetwlndsewlrekittqqplvivvgtslavypfaslpeeiprkvkrv
lcnletvgdfkankrptdlivhqysdefaeqlveelgwqedfekilta

Timeline for d1szca1:

• d1szca1 first appeared in SCOP 1.69, called d1szca_
  
• d1szca1 appears in SCOPe 2.07