SCOP 1.75: Domain d1sr5.1: 1sr5 B:,C:

Lineage for d1sr5.1 (1sr5 B:,C:)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (47 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (164 PDB entries)
   Uniprot P00734 331-361,364-421
   Uniprot P00734 334-360 364-510 518-619
   Uniprot P00734 328-620
   Uniprot P00734 355-621
   Uniprot P00734 328-620
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d1sr5.1: 1sr5 B:,C: [105951]
   Other proteins in same PDB: d1sr5a_
   complexed with nag, nt1, nt2

Details for d1sr5.1

PDB Entry: 1sr5, 3.1 Å

PDB Description: antithrombin-anhydrothrombin-heparin ternary complex structure

PDB Compounds: (B:) Prothrombin, (C:) Prothrombin

SCOP Domain Sequences for d1sr5.1:

Sequence, based on SEQRES records:

>g1sr5.1 b.47.1.2 (B:,C:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
fgsgeadcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqell
cgaslisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyih
prynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlket
wtanvgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsgg
pfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidq

Sequence, based on observed residues (ATOM records):

>g1sr5.1 b.47.1.2 (B:,C:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
fgsgeadcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqell
cgaslisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyih
prynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlkeg
qpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspf
nnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidq

Timeline for d1sr5.1:

• d1sr5.1 first appeared in SCOP 1.69
  
• d1sr5.1 appears in SCOP 1.73
  
• d1sr5.1 appears in SCOPe 2.01
  
• d1sr5.1 appears in the current release, SCOPe 2.08