Lineage for d1sqia2 (1sqi A:157-366)

  1. Root: SCOP 1.69
  2. 496776Class d: Alpha and beta proteins (a+b) [53931] (279 folds)
  3. 502238Fold d.32: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1 superfamily)
    beta-alpha-beta(3); 2 layers: alpha/beta
  4. 502239Superfamily d.32.1: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54593] (8 families) (S)
  5. 502320Family d.32.1.3: Extradiol dioxygenases [54602] (4 proteins)
    duplication: consists of 2 similar domains with 2 repeats in each
    Similar to the Methylmalonyl-CoA epimerase dimer
  6. 502356Protein 4-hydroxyphenylpyruvate dioxygenase, HppD [54608] (5 species)
  7. 502366Species Human (Homo sapiens) [TaxId:9606] [110878] (1 PDB entry)
  8. 502368Domain d1sqia2: 1sqi A:157-366 [105915]

Details for d1sqia2

PDB Entry: 1sqi (more details), 2.15 Å

PDB Description: Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases

SCOP Domain Sequences for d1sqia2:

Sequence, based on SEQRES records: (download)

>d1sqia2 d.32.1.3 (A:157-366) 4-hydroxyphenylpyruvate dioxygenase, HppD {Human (Homo sapiens)}
lpgfeaptykdtllpklpscnleiidhivgnqpdqemesasewylknlqfhrfwsvddtq
vhteysslrsivvanyeesikmpinepapgrkksqiqeyvdynggagvqhialrtediit
tirhlrergmeflavpssyyrllrenlktskiqvkenmdvleelkilvdydekgyllqif
tkpmqdrptlfleviqrhnhqgfgagnfns

Sequence, based on observed residues (ATOM records): (download)

>d1sqia2 d.32.1.3 (A:157-366) 4-hydroxyphenylpyruvate dioxygenase, HppD {Human (Homo sapiens)}
lpgfeaptykdtllpklpscnleiidhivgnqpdqemesasewylknlqfhrfwsvlrsi
vvanyeesikmpinepasqiqeyvdynggagvqhialrtediittirhlrergmeflavp
ssyyrllrenlktskiqvkenmdvleelkilvdydekgyllqiftkpmqdrptlfleviq
rhnhqgfgagnfns

SCOP Domain Coordinates for d1sqia2:

Click to download the PDB-style file with coordinates for d1sqia2.
(The format of our PDB-style files is described here.)

Timeline for d1sqia2:

View in 3D
Domains from same chain:
(mouse over for more information)
d1sqia1