SCOP 1.71: Domain d1sk6b_: 1sk6 B:

Lineage for d1sk6b_ (1sk6 B:)

1. Root: SCOP 1.71

2. Class e: Multi-domain proteins (alpha and beta) [56572] (48 folds)

3. Fold e.41: Adenylylcyclase toxin (the edema factor) [81299] (1 superfamily)
   3 domains: (1&2) alpha+beta, with domain 2 being inserted in domain 1; (3) all-alpha

4. Superfamily e.41.1: Adenylylcyclase toxin (the edema factor) [81298] (1 family)
   Domain 1 has topological and active site similarity to the Nucleotidyltransferases (eg. 1kny N-domain); domain 3 binds calmodulin

5. Family e.41.1.1: Adenylylcyclase toxin (the edema factor) [69887] (1 protein)
   decorated with many insertions and the C-terminal domain

6. Protein Adenylylcyclase toxin (the edema factor) [69888] (1 species)

7. Species Bacillus anthracis [TaxId:1392] [69889] (7 PDB entries)

8. Domain d1sk6b_: 1sk6 B: [105666]
   Other proteins in same PDB: d1sk6d_, d1sk6e_, d1sk6f_

Details for d1sk6b_

PDB Entry: 1sk6, 3.2 Å

PDB Description: crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin, 3',5' cyclic amp (camp), and pyrophosphate

SCOP Domain Sequences for d1sk6b_:

Sequence, based on SEQRES records:

>d1sk6b_ e.41.1.1 (B:) Adenylylcyclase toxin (the edema factor) {Bacillus anthracis}
dvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvhgk
ssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrieel
kengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnwrn
ievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvtnll
ikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdnei
fiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitkak
intiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanhifs
qekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqksnief
kllykqlnftenetdnfevfqkiid

Sequence, based on observed residues (ATOM records):

>d1sk6b_ e.41.1.1 (B:) Adenylylcyclase toxin (the edema factor) {Bacillus anthracis}
dvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvhgk
ssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrieel
kengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnwrn
ievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnekqkgvtnllik
ygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdneifi
inpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitkakin
tipsdyynsanhifsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritn
qvqlllthqkllykqlnftenetdnfevfqkiid

Timeline for d1sk6b_:

• d1sk6b_ first appeared in SCOP 1.69
  
• d1sk6b_ appears in SCOP 1.73
  
• d1sk6b_ appears in the current release, SCOPe 2.08