SCOPe 2.06: Domain d1shla_: 1shl A:

Lineage for d1shla_ (1shl A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Caspase-7 [63961] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63962] (12 PDB entries)
   Uniprot P55210 57-303

8. Domain d1shla_: 1shl A: [105556]
   complexed with fxn

Details for d1shla_

PDB Entry: 1shl, 3 Å

PDB Description: caspase-7 in complex with fica allosteric inhibitor

PDB Compounds: (A:) caspase-7

SCOPe Domain Sequences for d1shla_:

Sequence, based on SEQRES records:

>d1shla_ c.17.1.1 (A:) Caspase-7 {Human (Homo sapiens) [TaxId: 9606]}
tyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcsc
akmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktlle
kpklffiqacrgteladgiqadsrykipveadflfaystvpgyyswrspgrgswfvqalc
sileehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsmltkelyfsq

Sequence, based on observed residues (ATOM records):

>d1shla_ c.17.1.1 (A:) Caspase-7 {Human (Homo sapiens) [TaxId: 9606]}
tyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcsc
akmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktlle
kpklffiqacipveadflfaystvrgswfvqalcsileehgkdleimqiltrvndrvarh
fqipcvvsmltkelyfsq

Timeline for d1shla_:

• d1shla_ first appeared in SCOP 1.69
  
• d1shla_ appears in SCOPe 2.05
  
• d1shla_ appears in SCOPe 2.07
  
• d1shla_ appears in the current release, SCOPe 2.08