SCOPe 2.08: Domain d1shja_: 1shj A:

Lineage for d1shja_ (1shj A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Caspase-7 [63961] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63962] (12 PDB entries)
   Uniprot P55210 57-303

8. Domain d1shja_: 1shj A: [105554]
   complexed with nxn, so4

Details for d1shja_

PDB Entry: 1shj, 2.8 Å

PDB Description: caspase-7 in complex with dica allosteric inhibitor

PDB Compounds: (A:) caspase-7

SCOPe Domain Sequences for d1shja_:

Sequence, based on SEQRES records:

>d1shja_ c.17.1.1 (A:) Caspase-7 {Human (Homo sapiens) [TaxId: 9606]}
tyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcsc
akmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgarcktlle
kpklffiqacrgtelddgiqadsgpindtdanprykipveadflfaystvpgyyswrspg
rgswfvqalcsileehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsmlt
kelyfsq

Sequence, based on observed residues (ATOM records):

>d1shja_ c.17.1.1 (A:) Caspase-7 {Human (Homo sapiens) [TaxId: 9606]}
tyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcsc
akmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgarcktlle
kpklffiqacrgteprykipveadflfaystvrgswfvqalcsileehgkdleimqiltr
vndrvarhfkkqipcvvsmltkelyfsq

Timeline for d1shja_:

• d1shja_ first appeared in SCOP 1.69
  
• d1shja_ appears in SCOPe 2.07