SCOPe 2.08: Domain d1sd2a_: 1sd2 A:

Lineage for d1sd2a_ (1sd2 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.2: Purine and uridine phosphorylases [53167] (2 families)
   complex architecture; contains mixed beta-sheet of 8 strands, order 23415867, strands 3, 6 & 7 are antiparallel to the rest; and barrel, closed; n=5, S=8

5. Family c.56.2.1: Purine and uridine phosphorylases [53168] (7 proteins)

6. Protein 5'-deoxy-5'-methylthioadenosine phosphorylase [53174] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53175] (17 PDB entries)
   Uniprot Q13126

8. Domain d1sd2a_: 1sd2 A: [105427]
   complexed with mth, so4

Details for d1sd2a_

PDB Entry: 1sd2, 2.1 Å

PDB Description: structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with 5'-methylthiotubercidin

PDB Compounds: (A:) 5'-methylthioadenosine phosphorylase

SCOPe Domain Sequences for d1sd2a_:

Sequence, based on SEQRES records:

>d1sd2a_ c.56.2.1 (A:) 5'-deoxy-5'-methylthioadenosine phosphorylase {Human (Homo sapiens) [TaxId: 9606]}
avkigiiggtglddpeilegrtekyvdtpfgkpsdalilgkiknvdcvllarhgrqhtim
pskvnyqaniwalkeegcthvivttacgslreeiqpgdiviidqfidrttmrpqsfydgs
hscargvchipmaepfcpktrevlietakklglrchskgtmvtiegprfssraesfmfrt
wgadvinmttvpevvlakeagicyasiamatdydcwkeheeavsvdrvlktlkenankak
slllttipqigstewsetlhnlknmaqfsvllp

Sequence, based on observed residues (ATOM records):

>d1sd2a_ c.56.2.1 (A:) 5'-deoxy-5'-methylthioadenosine phosphorylase {Human (Homo sapiens) [TaxId: 9606]}
avkigiiggtglddpeilegrtekyvdtpfgkpsdalilgkiknvdcvllarhgrqhtim
pskvnyqaniwalkeegcthvivttacgslreeiqpgdiviidqfidrttmrpqsfydgg
vchipmaepfcpktrevlietakklglrchskgtmvtiegprfssraesfmfrtwgadvi
nmttvpevvlakeagicyasiamatdydcwavsvdrvlktlkenankakslllttipqig
stewsetlhnlknmaqfsvllp

Timeline for d1sd2a_:

• d1sd2a_ first appeared in SCOP 1.69
  
• d1sd2a_ appears in SCOPe 2.07