SCOP 1.73: Domain d1s4bp_: 1s4b P:

Lineage for d1s4bp_ (1s4b P:)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (15 families)

5. Family d.92.1.5: Neurolysin-like [55505] (4 proteins)
   combines M2, M3 and M32 families of metalloproteases
   the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

6. Protein Neurolysin (endopeptidase 24.16, thimet oligopeptidase) [55506] (2 species)
   M3 family member; the thermolysin-like catalytic domain consists of residues 352-674

7. Species Human (Homo sapiens) [TaxId:9606] [111081] (1 PDB entry)

8. Domain d1s4bp_: 1s4b P: [105252]
   complexed with zn; mutant

Details for d1s4bp_

PDB Entry: 1s4b, 2 Å

PDB Description: crystal structure of human thimet oligopeptidase.

PDB Compounds: (P:) Thimet oligopeptidase

SCOP Domain Sequences for d1s4bp_:

Sequence; same for both SEQRES and ATOM records:

>d1s4bp_ d.92.1.5 (P:) Neurolysin (endopeptidase 24.16, thimet oligopeptidase) {Human (Homo sapiens) [TaxId: 9606]}
lrwdlsaqqieertrelieqtkrvydqvgtqefedvsyestlkaladvevtytvqrnild
fpqhvspskdirtasteadkklsefdvemsmredvyqrivwlqekvqkdslrpeaaryle
rliklgrrnglhlpretqenikrikkklsllcidfnknlnedttflpftlqelgglpedf
lnslekmedgklkvtlkyphyfpllkkchvpetrrkveeafnsrckeensailkelvtlr
aqksrllgfhthadyvlemnmaktsqtvatfldelaqklkplgeqeravilelkraecer
rglpfdgrirawdmryymnqveetrycvdqnllkeyfpvqvvthgllgiyqellglafhh
eegasawhedvrlytardaasgevvgkfyldlypregkyghaacfglqpgclrqdgsrqi
aiaamvanftkptadapsllqhdevetyfhefghvmhqlcsqaefamfsgthverdfvea
psqmlenwvweqepllrmsrhyrtgsavprellekliesrqantglfnlrqivlakvdqa
lhtqtdadpaeeyarlcqeilgvpatpgtnmpatfghlaggydaqyygylwsevysmdmf
htrfkqegvlnskvgmdyrscilrpggsedasamlrrflgrdpkqdafllskgl

Timeline for d1s4bp_:

• d1s4bp_ first appeared in SCOP 1.69
  
• d1s4bp_ appears in SCOP 1.71
  
• d1s4bp_ appears in SCOP 1.75
  
• d1s4bp_ appears in the current release, SCOPe 2.08