Lineage for d1s1xa2 (1s1x A:2-429)

  1. Root: SCOPe 2.07
  2. 2618030Class e: Multi-domain proteins (alpha and beta) [56572] (71 folds)
  3. 2622069Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
    divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
  4. 2622070Superfamily e.8.1: DNA/RNA polymerases [56672] (8 families) (S)
    "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain
  5. 2622423Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)
  6. 2622424Protein HIV-1 reverse transcriptase [56689] (4 species)
  7. 2622468Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (204 PDB entries)
    Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595
  8. 2622685Domain d1s1xa2: 1s1x A:2-429 [105218]
    Other proteins in same PDB: d1s1xa1
    complexed with nvp; mutant

Details for d1s1xa2

PDB Entry: 1s1x (more details), 2.8 Å

PDB Description: crystal structure of v108i mutant hiv-1 reverse transcriptase in complex with nevirapine
PDB Compounds: (A:) reverse transcriptase

SCOPe Domain Sequences for d1s1xa2:

Sequence, based on SEQRES records: (download)

>d1s1xa2 e.8.1.2 (A:2-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvf
aikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtildvgdayfsvpld
edfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviy
qymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtv
qpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeael
elaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgah
tndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpp
lvklwyql

Sequence, based on observed residues (ATOM records): (download)

>d1s1xa2 e.8.1.2 (A:2-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvf
aikkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtildvgdayfsvpldedfrk
ytaftipsinnetiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddly
vgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpe
kdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenre
ilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkql
teavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq
l

SCOPe Domain Coordinates for d1s1xa2:

Click to download the PDB-style file with coordinates for d1s1xa2.
(The format of our PDB-style files is described here.)

Timeline for d1s1xa2:

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Domains from same chain:
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d1s1xa1
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Domains from other chains:
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d1s1xb1