Lineage for d1rrja3 (1rrj A:201-430)

  1. Root: SCOP 1.73
  2. 742018Class e: Multi-domain proteins (alpha and beta) [56572] (53 folds)
  3. 743692Fold e.15: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1 superfamily)
    2 domains: alpha+beta and all-beta
  4. 743693Superfamily e.15.1: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56741] (1 family) (S)
  5. 743694Family e.15.1.1: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56742] (1 protein)
  6. 743695Protein Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56743] (2 species)
  7. 743698Species Human (Homo sapiens) [TaxId:9606] [56744] (15 PDB entries)
  8. 743701Domain d1rrja3: 1rrj A:201-430 [105080]
    Other proteins in same PDB: d1rrja1, d1rrja2
    complexed with ttc, ttg; mutant

Details for d1rrja3

PDB Entry: 1rrj (more details), 2.3 Å

PDB Description: Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
PDB Compounds: (A:) DNA topoisomerase I

SCOP Domain Sequences for d1rrja3:

Sequence; same for both SEQRES and ATOM records: (download)

>d1rrja3 e.15.1.1 (A:201-430) Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment {Human (Homo sapiens) [TaxId: 9606]}
qkwkwweeerypegikwkflehkgpvfappyeplpenvkfyydgkvmklspkaeevatff
akmldheyttkeifrknffkdwrkemtneekniitnlskcdftqmsqyfkaqtearkqms
keeklkikeenekllkeygfcimdnhkerianfkieppglfrgrgnhpkmgmlkrrimpe
diiincskdakvpspppghkwkevrhdnkvtwlvswteniqgsikyimln

SCOP Domain Coordinates for d1rrja3:

Click to download the PDB-style file with coordinates for d1rrja3.
(The format of our PDB-style files is described here.)

Timeline for d1rrja3: