SCOPe 2.04: Domain d1rrja1: 1rrj A:636-712

Lineage for d1rrja1 (1rrj A:636-712)

1. Root: SCOPe 2.04

2. Class a: All alpha proteins [46456] (285 folds)

3. Fold a.2: Long alpha-hairpin [46556] (20 superfamilies)
   2 helices; antiparallel hairpin, left-handed twist

4. Superfamily a.2.8: Eukaryotic DNA topoisomerase I, dispensable insert domain [46596] (1 family)

5. Family a.2.8.1: Eukaryotic DNA topoisomerase I, dispensable insert domain [46597] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, dispensable insert domain [46598] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [46599] (9 PDB entries)
   Uniprot P11387 203-767

8. Domain d1rrja1: 1rrj A:636-712 [105078]
   Other proteins in same PDB: d1rrja2, d1rrja3
   protein/DNA complex; complexed with ttg; mutant

Details for d1rrja1

PDB Entry: 1rrj, 2.3 Å

PDB Description: structural mechanisms of camptothecin resistance by mutations in human topoisomerase i

PDB Compounds: (A:) DNA topoisomerase I

SCOPe Domain Sequences for d1rrja1:

Sequence; same for both SEQRES and ATOM records:

>d1rrja1 a.2.8.1 (A:636-712) Eukaryotic DNA topoisomerase I, dispensable insert domain {Human (Homo sapiens) [TaxId: 9606]}
ppktfeksmmnlqtkidakkeqladarrdlksakadakvmkdaktkkvveskkkavqrle
eqlmklevqatdreenk

Timeline for d1rrja1:

• d1rrja1 first appeared in SCOP 1.69
  
• d1rrja1 appears in SCOPe 2.03
  
• d1rrja1 appears in SCOPe 2.05
  
• d1rrja1 appears in the current release, SCOPe 2.08