SCOPe 2.04: Domain d1rr8c2: 1rr8 C:201-430

Lineage for d1rr8c2 (1rr8 C:201-430)

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.15: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1 superfamily)
   2 domains: alpha+beta and all-beta

4. Superfamily e.15.1: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56741] (1 family)
   automatically mapped to Pfam PF02919

5. Family e.15.1.1: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56742] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56743] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56744] (15 PDB entries)
   Uniprot P11387 203-765 ! Uniprot P11387 203-767

8. Domain d1rr8c2: 1rr8 C:201-430 [105077]
   Other proteins in same PDB: d1rr8c1
   protein/DNA complex; complexed with ttg; mutant

Details for d1rr8c2

PDB Entry: 1rr8, 2.6 Å

PDB Description: structural mechanisms of camptothecin resistance by mutations in human topoisomerase i

PDB Compounds: (C:) DNA topoisomerase I

SCOPe Domain Sequences for d1rr8c2:

Sequence; same for both SEQRES and ATOM records:

>d1rr8c2 e.15.1.1 (C:201-430) Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment {Human (Homo sapiens) [TaxId: 9606]}
aawkwweeerypegikwkflehkgpvfappyeplpenvkfyydgkvmklspkaeevatff
akmldheyttkeifrknffkdwrkemtneekniitnlskcdftqmsqyfkaqtearkqms
keeklkikeenekllkeygfcimdnhkerianfkieppglsrgrgnhpkmgmlkrrimpe
diiincskdakvpspppghkwkevrhdnkvtwlvswteniqgsikyimln

Timeline for d1rr8c2:

• d1rr8c2 first appeared in SCOP 1.69
  
• d1rr8c2 appears in SCOPe 2.03
  
• d1rr8c2 appears in SCOPe 2.05
  
• d1rr8c2 appears in the current release, SCOPe 2.08