Lineage for d1rr8c1 (1rr8 C:431-608,C:708-765)

  1. Root: SCOP 1.73
  2. 713694Class d: Alpha and beta proteins (a+b) [53931] (334 folds)
  3. 737287Fold d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
    core: alpha3-beta3-alpha4; one side of beta-sheet is exposed
  4. 737288Superfamily d.163.1: DNA breaking-rejoining enzymes [56349] (2 families) (S)
  5. 737369Family d.163.1.2: Eukaryotic DNA topoisomerase I, catalytic core [56361] (1 protein)
  6. 737370Protein Eukaryotic DNA topoisomerase I, catalytic core [56362] (2 species)
  7. 737371Species Human (Homo sapiens) [TaxId:9606] [56363] (15 PDB entries)
  8. 737377Domain d1rr8c1: 1rr8 C:431-608,C:708-765 [105076]
    Other proteins in same PDB: d1rr8c2
    complexed with ttc, ttg; mutant

Details for d1rr8c1

PDB Entry: 1rr8 (more details), 2.6 Å

PDB Description: structural mechanisms of camptothecin resistance by mutations in human topoisomerase i
PDB Compounds: (C:) DNA topoisomerase I

SCOP Domain Sequences for d1rr8c1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1rr8c1 d.163.1.2 (C:431-608,C:708-765) Eukaryotic DNA topoisomerase I, catalytic core {Human (Homo sapiens) [TaxId: 9606]}

SCOP Domain Coordinates for d1rr8c1:

Click to download the PDB-style file with coordinates for d1rr8c1.
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Timeline for d1rr8c1: