SCOPe 2.07: Domain d1rqdb_: 1rqd B:

Lineage for d1rqdb_ (1rqd B:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.1: Deoxyhypusine synthase, DHS [52468] (2 proteins)
   automatically mapped to Pfam PF01916

6. Protein Deoxyhypusine synthase, DHS [52469] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52470] (13 PDB entries)
   Uniprot P49366

8. Domain d1rqdb_: 1rqd B: [105060]
   complexed with gc7, nad

Details for d1rqdb_

PDB Entry: 1rqd, 3 Å

PDB Description: deoxyhypusine synthase holoenzyme in its low ionic strength, high pH crystal form with the inhibitor GC7 bound in the active site

PDB Compounds: (B:) deoxyhypusine synthase

SCOPe Domain Sequences for d1rqdb_:

Sequence, based on SEQRES records:

>d1rqdb_ c.31.1.1 (B:) Deoxyhypusine synthase, DHS {Human (Homo sapiens) [TaxId: 9606]}
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplsqdedqhadl
tqsrrpltsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclapty
lgefslrgkelrenginrignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmi
arlgkeinnpesvyywaqknhipvfspaltdgslgdmiffhsyknpglvldivedlrlin
tqaifakctgmiilgggvvkhhiananlmrngadyavyintaqefdgsdsgarpdeavsw
gkirvdaqpvkvyadaslvfpllvaetfaqkmdafm

Sequence, based on observed residues (ATOM records):

>d1rqdb_ c.31.1.1 (B:) Deoxyhypusine synthase, DHS {Human (Homo sapiens) [TaxId: 9606]}
stqvrgydfnrgvnyralleafgttgfqatnfgravqqvnamiekkleplpltsctiflg
ytsnlissgiretirylvqhnmvdvlvttaggveedlikclaptylgefslrgkelreng
inrignllvpnenyckfedwlmpildqmvmeqntegvkwtpskmiarlgkeinnpesvyy
waqknhipvfspaltdgslgdmiffhsyknpglvldivedlrlintqaifakctgmiilg
ggvvkhhiananlmrngadyavyintaqefdgsdsgarpdeavswgkirvdaqpvkvyad
aslvfpllvaetfaqkmdafm

Timeline for d1rqdb_:

• d1rqdb_ first appeared in SCOP 1.69
  
• d1rqdb_ appears in SCOPe 2.06
  
• d1rqdb_ appears in the current release, SCOPe 2.08