SCOPe 2.08: Domain d1r74a_: 1r74 A:

Lineage for d1r74a_ (1r74 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.5: Glycine N-methyltransferase [53348] (1 protein)

6. Protein Glycine N-methyltransferase [53349] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110664] (2 PDB entries)
   Uniprot Q14749

8. Domain d1r74a_: 1r74 A: [104828]
   complexed with bme, cit

Details for d1r74a_

PDB Entry: 1r74, 2.55 Å

PDB Description: crystal structure of human glycine n-methyltransferase

PDB Compounds: (A:) glycine n-methyltransferase

SCOPe Domain Sequences for d1r74a_:

Sequence, based on SEQRES records:

>d1r74a_ c.66.1.5 (A:) Glycine N-methyltransferase {Human (Homo sapiens) [TaxId: 9606]}
yrtrslgvaaeglpdqyadgeaarvwqlyigdtrsrtaeykawllgllrqhgcqrvldva
cgtgvdsimlveegfsvtsvdasdkmlkyalkerwnrrhepafdkwvieeanwmtldkdv
pqsaeggfdaviclgnsfahlpdckgdqsehrlalkniasmvraggllvidhrnydhils
tgcappgkniyyksdltkdvttsvlivnnkahmvtldytvqvpgagqdgspglskfrlsy
yphclasftellqaafggkcqhsvlgdfkpykpgqtyipcyfihvlkrt

Sequence, based on observed residues (ATOM records):

>d1r74a_ c.66.1.5 (A:) Glycine N-methyltransferase {Human (Homo sapiens) [TaxId: 9606]}
yrtrslgvaaeglpdqyadgeaarvwqlyigdtrsrtaeykawllgllrqhgcqrvldva
cgtgvdsimlveegfsvtsvdasdkmlkyalkerwnrrhepafdkwvieeanwmtldkdv
peggfdaviclgnsfahlpdckgdqsehrlalkniasmvraggllvidhrnydhilstgc
appgkniyyksdltkdvttsvlivnnkahmvtldytvglskfrlsyyphclasftellqa
afggkcqhsvlgdfkpykpgqtyipcyfihvlkrt

Timeline for d1r74a_:

• d1r74a_ first appeared in SCOP 1.69
  
• d1r74a_ appears in SCOPe 2.07