SCOP 1.69: Domain d1r1ia_: 1r1i A:

Lineage for d1r1ia_ (1r1i A:)

1. Root: SCOP 1.69

2. Class d: Alpha and beta proteins (a+b) [53931] (279 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (15 families)

5. Family d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (1 protein)

6. Protein Neutral endopeptidase (neprilysin) [55503] (1 species)
   contains thermolysin-like catalytic domain (residues 419-749)
   the N-terminal half of the structure is multihelical

7. Species Human (Homo sapiens) [TaxId:9606] [55504] (4 PDB entries)

8. Domain d1r1ia_: 1r1i A: [104757]

Details for d1r1ia_

PDB Entry: 1r1i, 2.6 Å

PDB Description: structural analysis of neprilysin with various specific and potent inhibitors

SCOP Domain Sequences for d1r1ia_:

Sequence; same for both SEQRES and ATOM records:

>d1r1ia_ d.92.1.4 (A:) Neutral endopeptidase (neprilysin) {Human (Homo sapiens)}
gickssdciksaarliqnmdattepctdffkyacggwlkrnvipetssrygnfdilrdel
evvlkdvlqepktedivavqkakalyrscinesaidsrggepllkllpdiygwpvatenw
eqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidqprlglpsrdyyec
tgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelekeianatakpedrn
dpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitneedvvvyapeyltk
lkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalygttsetatwrrcany
vngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkraeekal
aikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdkde
wisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfddng
rnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlngintlgeniadngg
lgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpeyavnsiktdvhsp
gnfriigtlqnsaefseafhcrknsymnpekkcrvw

Timeline for d1r1ia_:

• d1r1ia_ is new in SCOP 1.69
  
• d1r1ia_ appears in SCOP 1.71
  
• d1r1ia_ appears in the current release, SCOPe 2.08