SCOPe 2.08: Domain d1r1ia_: 1r1i A:

Lineage for d1r1ia_ (1r1i A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ('zincins'), catalytic domain [55486] (18 families)

5. Family d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (2 proteins)

6. Protein Neutral endopeptidase (neprilysin) [55503] (1 species)
   contains thermolysin-like catalytic domain (residues 419-749)
   the N-terminal half of the structure is multihelical

7. Species Human (Homo sapiens) [TaxId:9606] [55504] (12 PDB entries)
   Uniprot P08473 54-749

8. Domain d1r1ia_: 1r1i A: [104757]
   complexed with nag, ti1, zn

Details for d1r1ia_

PDB Entry: 1r1i, 2.6 Å

PDB Description: structural analysis of neprilysin with various specific and potent inhibitors

PDB Compounds: (A:) Neprilysin

SCOPe Domain Sequences for d1r1ia_:

Sequence; same for both SEQRES and ATOM records:

>d1r1ia_ d.92.1.4 (A:) Neutral endopeptidase (neprilysin) {Human (Homo sapiens) [TaxId: 9606]}
gickssdciksaarliqnmdattepctdffkyacggwlkrnvipetssrygnfdilrdel
evvlkdvlqepktedivavqkakalyrscinesaidsrggepllkllpdiygwpvatenw
eqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidqprlglpsrdyyec
tgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelekeianatakpedrn
dpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitneedvvvyapeyltk
lkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalygttsetatwrrcany
vngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkraeekal
aikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdkde
wisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfddng
rnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlngintlgeniadngg
lgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpeyavnsiktdvhsp
gnfriigtlqnsaefseafhcrknsymnpekkcrvw

Timeline for d1r1ia_:

• d1r1ia_ first appeared in SCOP 1.69
  
• d1r1ia_ appears in SCOPe 2.07