SCOPe 2.07: Domain d1pzla_: 1pzl A:

Lineage for d1pzla_ (1pzl A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Hepatocyte nuclear factor 4-alpha [109605] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [109987] (1 PDB entry)
   Uniprot P41235 139-369

8. Domain d1pzla_: 1pzl A: [104393]
   Other proteins in same PDB: d1pzlb_
   complexed with myr

Details for d1pzla_

PDB Entry: 1pzl, 2.1 Å

PDB Description: crystal structure of hnf4a lbd in complex with the ligand and the coactivator src-1 peptide

PDB Compounds: (A:) Hepatocyte nuclear factor 4-alpha

SCOPe Domain Sequences for d1pzla_:

Sequence, based on SEQRES records:

>d1pzla_ a.123.1.1 (A:) Hepatocyte nuclear factor 4-alpha {Human (Homo sapiens) [TaxId: 9606]}
laslpsinallqaevlsrqitspvsgingdirakkiasiadvcesmkeqllvlvewakyi
pafcelplddqvallrahagehlllgatkrsmvfkdvlllgndyivprhcpelaemsrvs
irildelvlpfqelqiddneyaylkaiiffdpdakglsdpgkikrlrsqvqvsledyind
rqydsrgrfgelllllptlqsitwqmieqiqfiklfgmakidnllqemllggs

Sequence, based on observed residues (ATOM records):

>d1pzla_ a.123.1.1 (A:) Hepatocyte nuclear factor 4-alpha {Human (Homo sapiens) [TaxId: 9606]}
laslpsinallqaevlsrqitngdirakkiasiadvcesmkeqllvlvewakyipafcel
plddqvallrahagehlllgatkrsmvfkdvlllgndyivprhcpelaemsrvsirilde
lvlpfqelqiddneyaylkaiiffdpdakglsdpgkikrlrsqvqvsledyindrqydsr
grfgelllllptlqsitwqmieqiqfiklfgmakidnllqemllggs

Timeline for d1pzla_:

• d1pzla_ first appeared in SCOP 1.69
  
• d1pzla_ appears in SCOPe 2.06
  
• d1pzla_ appears in the current release, SCOPe 2.08