SCOPe 2.06: Domain d1pquc1: 1pqu C:1-133,C:358-371

Lineage for d1pquc1 (1pqu C:1-133,C:358-371)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (22 proteins)
   family members also share a common alpha+beta fold in C-terminal domain

6. Protein Aspartate beta-semialdehyde dehydrogenase [51813] (4 species)

7. Species Haemophilus influenzae [TaxId:727] [102159] (12 PDB entries)
   Uniprot P44801

8. Domain d1pquc1: 1pqu C:1-133,C:358-371 [104292]
   Other proteins in same PDB: d1pqua2, d1pqub2, d1pquc2, d1pqud2
   complexed with cac, cys, nap; mutant

Details for d1pquc1

PDB Entry: 1pqu, 1.92 Å

PDB Description: crystal structure of the h277n mutant of aspartate semialdehyde dehydrogenase from haemophilus influenzae bound with nadp, s-methyl cysteine sulfoxide and cacodylate

PDB Compounds: (C:) aspartate-semialdehyde dehydrogenase

SCOPe Domain Sequences for d1pquc1:

Sequence, based on SEQRES records:

>d1pquc1 c.2.1.3 (C:1-133,C:358-371) Aspartate beta-semialdehyde dehydrogenase {Haemophilus influenzae [TaxId: 727]}
mknvgfigwrgmvgsvlmdrmsqendfenlnpvffttsqagqkapvfggkdagdlksafd
ieelkkldiivtcqggdytnevypklkatgwdgywvdaasalrmkddaiivldpvnqhvi
seglkkgiktfvgXaaepvrrilkqlva

Sequence, based on observed residues (ATOM records):

>d1pquc1 c.2.1.3 (C:1-133,C:358-371) Aspartate beta-semialdehyde dehydrogenase {Haemophilus influenzae [TaxId: 727]}
mknvgfigwrgmvgsvlmdrmsqendfenlnpvffttsqlksafdieelkkldiivtcqg
gdytnevypklkatgwdgywvdaasalrmkddaiivldpvnqhviseglkkgiktfvgXa
aepvrrilkqlva

Timeline for d1pquc1:

• d1pquc1 first appeared in SCOP 1.69
  
• d1pquc1 appears in SCOPe 2.05
  
• d1pquc1 appears in SCOPe 2.07
  
• d1pquc1 appears in the current release, SCOPe 2.08