SCOP 1.73: Domain d1pqpa1: 1pqp A:1-133,A:358-371

Lineage for d1pqpa1 (1pqp A:1-133,A:358-371)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (22 proteins)
   family members also share a common alpha+beta fold in C-terminal domain

6. Protein Aspartate beta-semialdehyde dehydrogenase [51813] (4 species)

7. Species Haemophilus influenzae [TaxId:727] [102159] (12 PDB entries)

8. Domain d1pqpa1: 1pqp A:1-133,A:358-371 [104286]
   Other proteins in same PDB: d1pqpa2
   complexed with as2, po4; mutant

Details for d1pqpa1

PDB Entry: 1pqp, 2.06 Å

PDB Description: crystal structure of the c136s mutant of aspartate semialdehyde dehydrogenase from haemophilus influenzae bound with aspartate semialdehyde and phosphate

PDB Compounds: (A:) aspartate-semialdehyde dehydrogenase

SCOP Domain Sequences for d1pqpa1:

Sequence, based on SEQRES records:

>d1pqpa1 c.2.1.3 (A:1-133,A:358-371) Aspartate beta-semialdehyde dehydrogenase {Haemophilus influenzae [TaxId: 727]}
mknvgfigwrgmvgsvlmdrmsqendfenlnpvffttsqagqkapvfggkdagdlksafd
ieelkkldiivtcqggdytnevypklkatgwdgywvdaasalrmkddaiivldpvnqhvi
seglkkgiktfvgXaaepvrrilkqlva

Sequence, based on observed residues (ATOM records):

>d1pqpa1 c.2.1.3 (A:1-133,A:358-371) Aspartate beta-semialdehyde dehydrogenase {Haemophilus influenzae [TaxId: 727]}
mknvgfigwrgmvgsvlmdrmsqendfenlnpvffttsqalksafdieelkkldiivtcq
ggdytnevypklkatgwdgywvdaasalrmkddaiivldpvnqhviseglkkgiktfvgX
aaepvrrilkqlva

Timeline for d1pqpa1:

• d1pqpa1 first appeared in SCOP 1.69
  
• d1pqpa1 appears in SCOP 1.71
  
• d1pqpa1 appears in SCOP 1.75
  
• d1pqpa1 appears in the current release, SCOPe 2.08