SCOPe 2.08: Domain d1of1a_: 1of1 A:

Lineage for d1of1a_ (1of1 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Thymidine kinase [52552] (4 species)
   contains insert all-alpha subdomain, res. 251-322

7. Species Herpes simplex virus type 1, different strains [TaxId:10298] [52553] (33 PDB entries)
   Uniprot P03176 46-375

8. Domain d1of1a_: 1of1 A: [103924]
   complexed with sct, so4
   has additional subdomain(s) that are not in the common domain

Details for d1of1a_

PDB Entry: 1of1, 1.95 Å

PDB Description: kinetics and crystal structure of the herpes simplex virus type 1 thymidine kinase interacting with (south)-methanocarba-thymidine

PDB Compounds: (A:) Thymidine kinase

SCOPe Domain Sequences for d1of1a_:

Sequence, based on SEQRES records:

>d1of1a_ c.37.1.1 (A:) Thymidine kinase {Herpes simplex virus type 1, different strains [TaxId: 10298]}
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhp
iaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpge
rldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphig
dtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlts
gmvqthvttpgsipticdlartfaremgea

Sequence, based on observed residues (ATOM records):

>d1of1a_ c.37.1.1 (A:) Thymidine kinase {Herpes simplex virus type 1, different strains [TaxId: 10298]}
mptllrvyidgphgmgkttttqllvaddivyvpepmtywrvlgasetianiyttqhrldq
geisagdaavvmtsaqitmgmpyavtdavlaphiggeapppaltlifdrhpiaallcypa
arylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpgerldlamlaa
irrvygllantvrylqcggswredwgqlsgtgprphigdtlftlfrapellapngdlynv
fawaldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdlart
faremgea

Timeline for d1of1a_:

• d1of1a_ first appeared in SCOP 1.69
  
• d1of1a_ appears in SCOPe 2.07