SCOPe 2.08: Domain d1o5eh_: 1o5e H:

Lineage for d1o5eh_ (1o5e H:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Hepsin, catalytic domain [101813] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101814] (4 PDB entries)
   Uniprot P05981 163-417

8. Domain d1o5eh_: 1o5e H: [103885]
   Other proteins in same PDB: d1o5el_
   complexed with 132

Details for d1o5eh_

PDB Entry: 1o5e, 1.75 Å

PDB Description: dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa)

PDB Compounds: (H:) Serine protease hepsin

SCOPe Domain Sequences for d1o5eh_:

Sequence, based on SEQRES records:

>d1o5eh_ b.47.1.2 (H:) Hepsin, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
ivggrdtslgrwpwqvslrydgahlcggsllsgdwvltaahcfpernrvlsrwrvfagav
aqasphglqlgvqavvyhggylpfrdpnseensndialvhlssplplteyiqpvclpaag
qalvdgkictvtgwgntqyygqqagvlqearvpiisndvcngadfygnqikpkmfcagyp
eggidacqgdsggpfvcedsisrtprwrlcgivswgtgcalaqkpgvytkvsdfrewifq
aikthseasgmvtql

Sequence, based on observed residues (ATOM records):

>d1o5eh_ b.47.1.2 (H:) Hepsin, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
ivggrdtslgrwpwqvslrydgahlcggsllsgdwvltaahcfpernrvlsrwrvfagav
aqasphglqlgvqavvyhggylpfnsndialvhlssplplteyiqpvclpaagqalvdgk
ictvtgwgntqyygqqagvlqearvpiisndvcngadfygnqikpkmfcagypeggidac
qgdsggpfvcedsisrtprwrlcgivswgtgcalaqkpgvytkvsdfrewifqaikthse
asgmvtql

Timeline for d1o5eh_:

• d1o5eh_ first appeared in SCOP 1.69
  
• d1o5eh_ appears in SCOPe 2.07