SCOPe 2.06: Family a.238.1.1: BAR domain

Lineage for Family a.238.1.1: BAR domain

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.238: BAR/IMD domain-like [116747] (1 superfamily)
   6 helices, homodimer of 3-helical domains

4. Superfamily a.238.1: BAR/IMD domain-like [103657] (5 families)
   core: dimeric six-helical bundle; protuding long helices form aniparallel coiled coils at both bundle ends

5. Family a.238.1.1: BAR domain [103658] (4 proteins)
   sensor of membrane curvature

Proteins:

1. Amphiphysin [103659] (1 species)

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [103660] (1 PDB entry)

2. DCC-interacting protein 13-alpha, APPL1 [158643] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [158644] (1 PDB entry)
     Uniprot Q9UKG1 6-273

3. Endophilin-1 [140699] (3 species)
   SH3-containing GRB2-like protein 2

   1. Species Human (Homo sapiens) [TaxId:9606] [140701] (3 PDB entries)
      Uniprot Q99962 11-247! Uniprot Q99962 26-247

   2. Species Mouse (Mus musculus) [TaxId:10090] [140702] (1 PDB entry)
      Uniprot Q62420 27-246

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [140700] (1 PDB entry)
      Uniprot Q62420 25-247
      UniProt sequence of Rat species, O35179, is a fragment that does not cover the entire domain

4. automated matches [190594] (1 species)
   not a true protein

   • Species Human (Homo sapiens) [TaxId:9606] [187606] (5 PDB entries)

More info for Family a.238.1.1: BAR domain

Timeline for Family a.238.1.1: BAR domain:

• Family a.238.1.1: BAR domain first appeared in SCOP 1.67, called Family h.4.14.1: BAR domain
  
• Family a.238.1.1: BAR domain appears in SCOPe 2.05
  
• Family a.238.1.1: BAR domain appears in SCOPe 2.07
  
• Family a.238.1.1: BAR domain appears in the current release, SCOPe 2.08