SCOPe 2.08: Protein: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA

Lineage for Protein: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
consists of two intertwined (sub)domains related by pseudo dyad; duplication
3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
the constituent families form similar dimers
Family c.77.1.3: PdxA-like [102656] (2 proteins)
Pfam PF04166; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PlsX-like and phosphotransacetylase families
Protein 4-hydroxythreonine-4-phosphate dehydrogenase PdxA [102657] (2 species)
pyridoxal phosphate biosynthetic protein

Species:

Escherichia coli [TaxId:562] [102658] (3 PDB entries)
1. Domains for 1ps6:
  1. Domain d1ps6a_: 1ps6 A: [95070]
    complexed with 4tp, zn
  2. Domain d1ps6b_: 1ps6 B: [95071]
    complexed with 4tp, zn
2. Domains for 1ps7:
  1. Domain d1ps7a_: 1ps7 A: [95072]
    complexed with zn
  2. Domain d1ps7b_: 1ps7 B: [95073]
    complexed with zn
  3. Domain d1ps7c_: 1ps7 C: [95074]
    complexed with zn
  4. Domain d1ps7d_: 1ps7 D: [95075]
    complexed with zn
3. Domains for 1ptm:
  1. Domain d1ptma_: 1ptm A: [95104]
    complexed with po4, zn
  2. Domain d1ptmb_: 1ptm B: [95105]
    complexed with po4, zn
Salmonella typhimurium [TaxId:90371] [102659] (1 PDB entry)
- Domains for 1r8k:
  1. Domain d1r8ka_: 1r8k A: [97240]
    complexed with cl, co, so4
  2. Domain d1r8kb_: 1r8k B: [97241]
    complexed with cl, co, so4

More info for Protein 4-hydroxythreonine-4-phosphate dehydrogenase PdxA from c.77.1.3: PdxA-like

Timeline for Protein 4-hydroxythreonine-4-phosphate dehydrogenase PdxA from c.77.1.3: PdxA-like:

Protein 4-hydroxythreonine-4-phosphate dehydrogenase PdxA from c.77.1.3: PdxA-like first appeared in SCOP 1.67
Protein 4-hydroxythreonine-4-phosphate dehydrogenase PdxA from c.77.1.3: PdxA-like appears in SCOPe 2.07