Lineage for Protein: Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain

  1. Root: SCOPe 2.04
  2. 1565955Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1593542Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 1593543Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families) (S)
    division into families based on beta-sheet topologies
  5. 1596847Family c.37.1.12: ABC transporter ATPase domain-like [52686] (24 proteins)
    there are two additional subdomains inserted into the central core that has a RecA-like topology
  6. 1596863Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378] (2 species)

Species:

  1. 1596864Human (Homo sapiens) [TaxId:9606] [117543] (8 PDB entries)
    Uniprot P13569 389-671
    1. Domains for 1xmi:
      1. 1596873Domain d1xmia_: 1xmi A: [115489]
        complexed with atp, mg
      2. 1596874Domain d1xmib_: 1xmi B: [115490]
        complexed with atp, mg
      3. 1596875Domain d1xmic_: 1xmi C: [115491]
        complexed with atp, mg
      4. 1596876Domain d1xmid_: 1xmi D: [115492]
        complexed with atp, mg
      5. 1596877Domain d1xmie_: 1xmi E: [115493]
        complexed with atp, mg
    2. Domain for 1xmj:
    3. Domain for 2bbo:
    4. Domains for 2bbs:
      1. 1596871Domain d2bbsa_: 2bbs A: [163032]
        automated match to d1xmid_
        complexed with atp, mg; mutant
      2. 1596872Domain d2bbsb_: 2bbs B: [163033]
        automated match to d1xmid_
        complexed with atp, mg; mutant
    5. Domains for 2bbt:
      1. 1596878Domain d2bbta_: 2bbt A: [163034]
        automated match to d1xmid_
        complexed with atp, mg; mutant
      2. 1596879Domain d2bbtb_: 2bbt B: [163035]
        automated match to d1xmid_
        complexed with atp, mg; mutant
    6. Domains for 2pze:
      1. 1596865Domain d2pzea_: 2pze A: [231179]
        automated match to d2pzeb_
        complexed with atp, mg
      2. 1596866Domain d2pzeb_: 2pze B: [205696]
        automated match to d1l2ta_
        complexed with atp, mg
    7. Domains for 2pzf:
      1. 1596869Domain d2pzfa_: 2pzf A: [231180]
        automated match to d2pzfb_
        complexed with atp, mg
      2. 1596870Domain d2pzfb_: 2pzf B: [205697]
        automated match to d1l2ta_
        complexed with atp, mg
    8. Domains for 2pzg:
      1. 1596867Domain d2pzga_: 2pzg A: [231181]
        automated match to d2pzgb_
        complexed with atp, gol, mg
      2. 1596868Domain d2pzgb_: 2pzg B: [205698]
        automated match to d1l2ta_
        complexed with atp, gol, mg
  2. 1596882Mouse (Mus musculus) [TaxId:10090] [102379] (9 PDB entries)
    Uniprot P26361 390-670
    1. Domains for 1q3h:
      1. 1596899Domain d1q3ha_: 1q3h A: [95688]
        complexed with acy, anp, mg
      2. 1596900Domain d1q3hb_: 1q3h B: [95689]
        complexed with acy, anp, mg
      3. 1596901Domain d1q3hc_: 1q3h C: [95690]
        complexed with acy, anp, mg
      4. 1596902Domain d1q3hd_: 1q3h D: [95691]
        complexed with acy, anp, mg
    2. Domains for 1r0w:
      1. 1596887Domain d1r0wa_: 1r0w A: [96754]
        complexed with acy
      2. 1596888Domain d1r0wb_: 1r0w B: [96755]
        complexed with acy
      3. 1596889Domain d1r0wc_: 1r0w C: [96756]
        complexed with acy
      4. 1596890Domain d1r0wd_: 1r0w D: [96757]
        complexed with acy
    3. Domains for 1r0x:
      1. 1596891Domain d1r0xa_: 1r0x A: [96758]
        complexed with acy, atp, mg
      2. 1596892Domain d1r0xb_: 1r0x B: [96759]
        complexed with acy, atp, mg
      3. 1596893Domain d1r0xc_: 1r0x C: [96760]
        complexed with acy, atp, mg
      4. 1596894Domain d1r0xd_: 1r0x D: [96761]
        complexed with acy, atp, mg
    4. Domains for 1r0y:
      1. 1596903Domain d1r0ya_: 1r0y A: [96762]
        complexed with acy, adp
      2. 1596904Domain d1r0yb_: 1r0y B: [96763]
        complexed with acy, adp
      3. 1596905Domain d1r0yc_: 1r0y C: [96764]
        complexed with acy, adp
      4. 1596906Domain d1r0yd_: 1r0y D: [96765]
        complexed with acy, adp
    5. Domains for 1r0z:
      1. 1596895Domain d1r0za_: 1r0z A: [96766]
        complexed with acy, atp, mg
      2. 1596896Domain d1r0zb_: 1r0z B: [96767]
        complexed with acy, atp, mg
      3. 1596897Domain d1r0zc_: 1r0z C: [96768]
        complexed with acy, atp, mg
      4. 1596898Domain d1r0zd_: 1r0z D: [96769]
        complexed with acy, atp, mg
    6. Domains for 1r10:
      1. 1596911Domain d1r10a_: 1r10 A: [96770]
        complexed with acy, atp, mg
      2. 1596912Domain d1r10b_: 1r10 B: [96771]
        complexed with acy, atp, mg
    7. Domains for 1xf9:
      1. 1596907Domain d1xf9a_: 1xf9 A: [115245]
        complexed with acy, atp, mg; mutant
      2. 1596908Domain d1xf9b_: 1xf9 B: [115246]
        complexed with acy, atp, mg; mutant
      3. 1596909Domain d1xf9c_: 1xf9 C: [115247]
        complexed with acy, atp, mg; mutant
      4. 1596910Domain d1xf9d_: 1xf9 D: [115248]
        complexed with acy, atp, mg; mutant
    8. Domains for 1xfa:
      1. 1596913Domain d1xfaa_: 1xfa A: [115249]
        complexed with acy, atp, cl, mg; mutant
      2. 1596914Domain d1xfab_: 1xfa B: [115250]
        complexed with acy, atp, cl, mg; mutant
    9. Domains for 3si7:
      1. 1596883Domain d3si7a_: 3si7 A: [185410]
        automated match to d1q3hc_
        complexed with act, atp, mg; mutant
      2. 1596884Domain d3si7b_: 3si7 B: [185411]
        automated match to d1q3hc_
        complexed with act, atp, mg; mutant
      3. 1596885Domain d3si7c_: 3si7 C: [185412]
        automated match to d1q3hc_
        complexed with act, atp, mg; mutant
      4. 1596886Domain d3si7d_: 3si7 D: [185413]
        automated match to d1q3hc_
        complexed with act, atp, mg; mutant

More info for Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like

Timeline for Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like:

  • Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like first appeared in SCOP 1.67
  • Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like appears in SCOPe 2.03
  • Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like appears in SCOPe 2.05
  • Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like appears in the current release, SCOPe 2.08