Lineage for Protein: Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2109203Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2109204Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families) (S)
    division into families based on beta-sheet topologies
  5. 2112785Family c.37.1.12: ABC transporter ATPase domain-like [52686] (25 protein domains)
    there are two additional subdomains inserted into the central core that has a RecA-like topology
  6. 2112801Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378] (2 species)

Species:

  1. 2112802Human (Homo sapiens) [TaxId:9606] [117543] (9 PDB entries)
    Uniprot P13569 389-671
    1. Domains for 1xmi:
      1. 2112811Domain d1xmia1: 1xmi A:389-671 [115489]
        Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
        complexed with atp, mg
      2. 2112812Domain d1xmib1: 1xmi B:389-671 [115490]
        Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
        complexed with atp, mg
      3. 2112813Domain d1xmic_: 1xmi C: [115491]
        Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
        complexed with atp, mg
      4. 2112814Domain d1xmid1: 1xmi D:389-672 [115492]
        Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
        complexed with atp, mg
      5. 2112815Domain d1xmie_: 1xmi E: [115493]
        Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
        complexed with atp, mg
    2. Domain for 1xmj:
    3. Domain for 2bbo:
    4. Domains for 2bbs:
      1. 2112809Domain d2bbsa1: 2bbs A:389-671 [163032]
        Other proteins in same PDB: d2bbsa2
        automated match to d1xmid_
        complexed with atp, mg; mutant
      2. 2112810Domain d2bbsb_: 2bbs B: [163033]
        Other proteins in same PDB: d2bbsa2
        automated match to d1xmid_
        complexed with atp, mg; mutant
    5. Domains for 2bbt:
      1. 2112816Domain d2bbta_: 2bbt A: [163034]
        automated match to d1xmid_
        complexed with atp, mg; mutant
      2. 2112817Domain d2bbtb_: 2bbt B: [163035]
        automated match to d1xmid_
        complexed with atp, mg; mutant
    6. Domains for 2pze:
      1. 2112803Domain d2pzea1: 2pze A:387-645 [231179]
        Other proteins in same PDB: d2pzea2
        automated match to d2pzeb_
        complexed with atp, mg
      2. 2112804Domain d2pzeb_: 2pze B: [205696]
        Other proteins in same PDB: d2pzea2
        automated match to d1l2ta_
        complexed with atp, mg
    7. Domains for 2pzf:
      1. 2112807Domain d2pzfa1: 2pzf A:387-646 [231180]
        Other proteins in same PDB: d2pzfa2
        automated match to d2pzfb_
        complexed with atp, mg
      2. 2112808Domain d2pzfb_: 2pzf B: [205697]
        Other proteins in same PDB: d2pzfa2
        automated match to d1l2ta_
        complexed with atp, mg
    8. Domains for 2pzg:
      1. 2112805Domain d2pzga_: 2pzg A: [231181]
        automated match to d2pzgb_
        complexed with atp, gol, mg
      2. 2112806Domain d2pzgb_: 2pzg B: [205698]
        automated match to d1l2ta_
        complexed with atp, gol, mg
    9. Domain for 4wz6:
  2. 2112821Mouse (Mus musculus) [TaxId:10090] [102379] (9 PDB entries)
    Uniprot P26361 390-670
    1. Domains for 1q3h:
      1. 2112838Domain d1q3ha_: 1q3h A: [95688]
        Other proteins in same PDB: d1q3hc2
        complexed with acy, anp, mg
      2. 2112839Domain d1q3hb_: 1q3h B: [95689]
        Other proteins in same PDB: d1q3hc2
        complexed with acy, anp, mg
      3. 2112840Domain d1q3hc1: 1q3h C:389-670 [95690]
        Other proteins in same PDB: d1q3hc2
        complexed with acy, anp, mg
      4. 2112841Domain d1q3hd_: 1q3h D: [95691]
        Other proteins in same PDB: d1q3hc2
        complexed with acy, anp, mg
    2. Domains for 1r0w:
      1. 2112826Domain d1r0wa_: 1r0w A: [96754]
        Other proteins in same PDB: d1r0wc2
        complexed with acy
      2. 2112827Domain d1r0wb_: 1r0w B: [96755]
        Other proteins in same PDB: d1r0wc2
        complexed with acy
      3. 2112828Domain d1r0wc1: 1r0w C:389-670 [96756]
        Other proteins in same PDB: d1r0wc2
        complexed with acy
      4. 2112829Domain d1r0wd_: 1r0w D: [96757]
        Other proteins in same PDB: d1r0wc2
        complexed with acy
    3. Domains for 1r0x:
      1. 2112830Domain d1r0xa_: 1r0x A: [96758]
        Other proteins in same PDB: d1r0xc2
        complexed with acy, atp, mg
      2. 2112831Domain d1r0xb_: 1r0x B: [96759]
        Other proteins in same PDB: d1r0xc2
        complexed with acy, atp, mg
      3. 2112832Domain d1r0xc1: 1r0x C:389-670 [96760]
        Other proteins in same PDB: d1r0xc2
        complexed with acy, atp, mg
      4. 2112833Domain d1r0xd_: 1r0x D: [96761]
        Other proteins in same PDB: d1r0xc2
        complexed with acy, atp, mg
    4. Domains for 1r0y:
      1. 2112842Domain d1r0ya_: 1r0y A: [96762]
        Other proteins in same PDB: d1r0yc2
        complexed with acy, adp
      2. 2112843Domain d1r0yb_: 1r0y B: [96763]
        Other proteins in same PDB: d1r0yc2
        complexed with acy, adp
      3. 2112844Domain d1r0yc1: 1r0y C:389-670 [96764]
        Other proteins in same PDB: d1r0yc2
        complexed with acy, adp
      4. 2112845Domain d1r0yd_: 1r0y D: [96765]
        Other proteins in same PDB: d1r0yc2
        complexed with acy, adp
    5. Domains for 1r0z:
      1. 2112834Domain d1r0za_: 1r0z A: [96766]
        Other proteins in same PDB: d1r0zc2
        complexed with acy, atp, mg
      2. 2112835Domain d1r0zb_: 1r0z B: [96767]
        Other proteins in same PDB: d1r0zc2
        complexed with acy, atp, mg
      3. 2112836Domain d1r0zc1: 1r0z C:389-670 [96768]
        Other proteins in same PDB: d1r0zc2
        complexed with acy, atp, mg
      4. 2112837Domain d1r0zd_: 1r0z D: [96769]
        Other proteins in same PDB: d1r0zc2
        complexed with acy, atp, mg
    6. Domains for 1r10:
      1. 2112850Domain d1r10a_: 1r10 A: [96770]
        complexed with acy, atp, mg
      2. 2112851Domain d1r10b_: 1r10 B: [96771]
        complexed with acy, atp, mg
    7. Domains for 1xf9:
      1. 2112846Domain d1xf9a_: 1xf9 A: [115245]
        Other proteins in same PDB: d1xf9c2
        complexed with acy, atp, mg; mutant
      2. 2112847Domain d1xf9b_: 1xf9 B: [115246]
        Other proteins in same PDB: d1xf9c2
        complexed with acy, atp, mg; mutant
      3. 2112848Domain d1xf9c1: 1xf9 C:389-670 [115247]
        Other proteins in same PDB: d1xf9c2
        complexed with acy, atp, mg; mutant
      4. 2112849Domain d1xf9d_: 1xf9 D: [115248]
        Other proteins in same PDB: d1xf9c2
        complexed with acy, atp, mg; mutant
    8. Domains for 1xfa:
      1. 2112852Domain d1xfaa_: 1xfa A: [115249]
        complexed with acy, atp, cl, mg; mutant
      2. 2112853Domain d1xfab_: 1xfa B: [115250]
        complexed with acy, atp, cl, mg; mutant
    9. Domains for 3si7:
      1. 2112822Domain d3si7a_: 3si7 A: [185410]
        Other proteins in same PDB: d3si7c2
        automated match to d1q3hc_
        complexed with act, atp, mg; mutant
      2. 2112823Domain d3si7b_: 3si7 B: [185411]
        Other proteins in same PDB: d3si7c2
        automated match to d1q3hc_
        complexed with act, atp, mg; mutant
      3. 2112824Domain d3si7c1: 3si7 C:389-670 [185412]
        Other proteins in same PDB: d3si7c2
        automated match to d1q3hc_
        complexed with act, atp, mg; mutant
      4. 2112825Domain d3si7d_: 3si7 D: [185413]
        Other proteins in same PDB: d3si7c2
        automated match to d1q3hc_
        complexed with act, atp, mg; mutant

More info for Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like

Timeline for Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like:

  • Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like first appeared in SCOP 1.67
  • Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like appears in SCOPe 2.05