SCOPe 2.08: Protein: Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain

Lineage for Protein: Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
division into families based on beta-sheet topologies

Family c.37.1.12: ABC transporter ATPase domain-like [52686] (25 proteins)
there are two additional subdomains inserted into the central core that has a RecA-like topology
missing some secondary structures that made up less than one-third of the common domain

Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain [102378] (2 species)

Species:

Human (Homo sapiens) [TaxId:9606] [117543] (26 PDB entries)
Uniprot P13569 389-671

Domains for 1xmi:
1. Domain d1xmia1: 1xmi A:389-671 [115489]
  Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
  complexed with atp, mg
2. Domain d1xmib1: 1xmi B:389-671 [115490]
  Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
  complexed with atp, mg
3. Domain d1xmic_: 1xmi C: [115491]
  Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
  complexed with atp, mg
4. Domain d1xmid1: 1xmi D:389-672 [115492]
  Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
  complexed with atp, mg
5. Domain d1xmie_: 1xmi E: [115493]
  Other proteins in same PDB: d1xmia2, d1xmib2, d1xmid2
  complexed with atp, mg
Domain for 1xmj:
- Domain d1xmja_: 1xmj A: [115494]
  complexed with atp, mg
Domain for 2bbo:
- Domain d2bboa_: 2bbo A: [163031]
  automated match to d1xmja_
  complexed with atp, mg
Domains for 2bbs:
1. Domain d2bbsa1: 2bbs A:389-671 [163032]
  Other proteins in same PDB: d2bbsa2
  automated match to d1xmid_
  complexed with atp, mg; mutant
2. Domain d2bbsb_: 2bbs B: [163033]
  Other proteins in same PDB: d2bbsa2
  automated match to d1xmid_
  complexed with atp, mg; mutant
Domains for 2bbt:
1. Domain d2bbta_: 2bbt A: [163034]
  automated match to d1xmid_
  complexed with atp, mg; mutant
2. Domain d2bbtb_: 2bbt B: [163035]
  automated match to d1xmid_
  complexed with atp, mg; mutant
Domains for 2pze:
1. Domain d2pzea1: 2pze A:387-645 [231179]
  Other proteins in same PDB: d2pzea2
  automated match to d2pzeb_
  complexed with atp, mg
2. Domain d2pzeb_: 2pze B: [205696]
  Other proteins in same PDB: d2pzea2
  automated match to d1l2ta_
  complexed with atp, mg
Domains for 2pzf:
1. Domain d2pzfa1: 2pzf A:387-646 [231180]
  Other proteins in same PDB: d2pzfa2
  automated match to d2pzfb_
  complexed with atp, mg
2. Domain d2pzfb_: 2pzf B: [205697]
  Other proteins in same PDB: d2pzfa2
  automated match to d1l2ta_
  complexed with atp, mg
Domains for 2pzg:
1. Domain d2pzga_: 2pzg A: [231181]
  automated match to d2pzgb_
  complexed with atp, gol, mg
2. Domain d2pzgb_: 2pzg B: [205698]
  automated match to d1l2ta_
  complexed with atp, gol, mg
Domain for 4wz6:
- Domain d4wz6a_: 4wz6 A: [279356]
  automated match to d2bboa_
  complexed with atp, mg; mutant
Domain for 5tf7:
- Domain d5tf7a_: 5tf7 A: [351914]
  automated match to d2pzga_
  complexed with atp, mg
Domain for 5tf8:
- Domain d5tf8a_: 5tf8 A: [351898]
  automated match to d2pzga_
  complexed with mg, ttp
Domain for 5tfa:
- Domain d5tfaa_: 5tfa A: [351911]
  automated match to d2pzga_
  complexed with dut, mg
Domain for 5tfb:
- Domain d5tfba_: 5tfb A: [351922]
  automated match to d2pzga_
  complexed with mg, mgp
Domain for 5tfc:
- Domain d5tfca_: 5tfc A: [351975]
  automated match to d2pzga_
  complexed with gtp, mg
Domain for 5tfd:
- Domain d5tfda_: 5tfd A: [351926]
  automated match to d2pzga_
  complexed with ctp, mg
Domain for 5tff:
- Domain d5tffa_: 5tff A: [351998]
  automated match to d2pzga_
  complexed with mg, utp
Domain for 5tfg:
- Domain d5tfga_: 5tfg A: [351964]
  automated match to d2pzga_
  complexed with m5t, mg
Domain for 5tfi:
- Domain d5tfia_: 5tfi A: [351936]
  automated match to d2pzga_
  complexed with dgt, mg
Domain for 5tfj:
- Domain d5tfja_: 5tfj A: [351920]
  automated match to d2pzga_
  complexed with dcp, mg
Domain for 5tgk:
- Domain d5tgka_: 5tgk A: [351962]
  automated match to d2pzga_
  complexed with dtp, mg
Domains for 6gjq:
1. Domain d6gjqa_: 6gjq A: [369926]
  Other proteins in same PDB: d6gjqb1, d6gjqb2, d6gjqd1, d6gjqd2, d6gjqf1, d6gjqf2, d6gjqh1, d6gjqh2
  automated match to d2pzga_
  complexed with atp
2. Domain d6gjqe_: 6gjq E: [369931]
  Other proteins in same PDB: d6gjqb1, d6gjqb2, d6gjqd1, d6gjqd2, d6gjqf1, d6gjqf2, d6gjqh1, d6gjqh2
  automated match to d2pzga_
  complexed with atp
3. Domain d6gjqg_: 6gjq G: [369906]
  Other proteins in same PDB: d6gjqb1, d6gjqb2, d6gjqd1, d6gjqd2, d6gjqf1, d6gjqf2, d6gjqh1, d6gjqh2
  automated match to d2pzga_
  complexed with atp
Domain for 6gjs:
- Domain d6gjsa1: 6gjs A:387-636 [369881]
  Other proteins in same PDB: d6gjsa2, d6gjsb1, d6gjsb2, d6gjsc1, d6gjsc2
  automated match to d2pzga_
  complexed with atp, mg
Domains for 6gk4:
1. Domain d6gk4a_: 6gk4 A: [369980]
  Other proteins in same PDB: d6gk4b1, d6gk4b2, d6gk4c1, d6gk4c2, d6gk4e1, d6gk4e2, d6gk4f1, d6gk4f2
  automated match to d2pzga_
  complexed with atp, gol, mg
2. Domain d6gk4d_: 6gk4 D: [369933]
  Other proteins in same PDB: d6gk4b1, d6gk4b2, d6gk4c1, d6gk4c2, d6gk4e1, d6gk4e2, d6gk4f1, d6gk4f2
  automated match to d2pzga_
  complexed with atp, gol, mg

Domains for 6gkd:

Domain d6gkda_: 6gkd A: [369975]
Other proteins in same PDB: d6gkdb1, d6gkdb2, d6gkdc1, d6gkdc2, d6gkdg1, d6gkdg2, d6gkdh1, d6gkdh2, d6gkdj1, d6gkdj2, d6gkdk1, d6gkdk2, d6gkdm1, d6gkdm2, d6gkdn1, d6gkdn2, d6gkdp1, d6gkdp2, d6gkdq1, d6gkdq2, d6gkds1, d6gkds2, d6gkdt1, d6gkdt2
automated match to d2pzga_
complexed with atp, gol, mg

Domain d6gkdf_: 6gkd F: [370059]
Other proteins in same PDB: d6gkdb1, d6gkdb2, d6gkdc1, d6gkdc2, d6gkdg1, d6gkdg2, d6gkdh1, d6gkdh2, d6gkdj1, d6gkdj2, d6gkdk1, d6gkdk2, d6gkdm1, d6gkdm2, d6gkdn1, d6gkdn2, d6gkdp1, d6gkdp2, d6gkdq1, d6gkdq2, d6gkds1, d6gkds2, d6gkdt1, d6gkdt2
automated match to d2pzga_
complexed with atp, gol, mg

Domain d6gkdi_: 6gkd I: [369961]
Other proteins in same PDB: d6gkdb1, d6gkdb2, d6gkdc1, d6gkdc2, d6gkdg1, d6gkdg2, d6gkdh1, d6gkdh2, d6gkdj1, d6gkdj2, d6gkdk1, d6gkdk2, d6gkdm1, d6gkdm2, d6gkdn1, d6gkdn2, d6gkdp1, d6gkdp2, d6gkdq1, d6gkdq2, d6gkds1, d6gkds2, d6gkdt1, d6gkdt2
automated match to d2pzga_
complexed with atp, gol, mg

Domain d6gkdl_: 6gkd L: [369993]
Other proteins in same PDB: d6gkdb1, d6gkdb2, d6gkdc1, d6gkdc2, d6gkdg1, d6gkdg2, d6gkdh1, d6gkdh2, d6gkdj1, d6gkdj2, d6gkdk1, d6gkdk2, d6gkdm1, d6gkdm2, d6gkdn1, d6gkdn2, d6gkdp1, d6gkdp2, d6gkdq1, d6gkdq2, d6gkds1, d6gkds2, d6gkdt1, d6gkdt2
automated match to d2pzga_
complexed with atp, gol, mg

Domain d6gkdo_: 6gkd O: [369998]
Other proteins in same PDB: d6gkdb1, d6gkdb2, d6gkdc1, d6gkdc2, d6gkdg1, d6gkdg2, d6gkdh1, d6gkdh2, d6gkdj1, d6gkdj2, d6gkdk1, d6gkdk2, d6gkdm1, d6gkdm2, d6gkdn1, d6gkdn2, d6gkdp1, d6gkdp2, d6gkdq1, d6gkdq2, d6gkds1, d6gkds2, d6gkdt1, d6gkdt2
automated match to d2pzga_
complexed with atp, gol, mg

Domain d6gkdr_: 6gkd R: [369910]
Other proteins in same PDB: d6gkdb1, d6gkdb2, d6gkdc1, d6gkdc2, d6gkdg1, d6gkdg2, d6gkdh1, d6gkdh2, d6gkdj1, d6gkdj2, d6gkdk1, d6gkdk2, d6gkdm1, d6gkdm2, d6gkdn1, d6gkdn2, d6gkdp1, d6gkdp2, d6gkdq1, d6gkdq2, d6gkds1, d6gkds2, d6gkdt1, d6gkdt2
automated match to d2pzga_
complexed with atp, gol, mg

Domains for 6wbs:
1. Domain d6wbsa_: 6wbs A: [402729]
  automated match to d2pzga_
  complexed with atp, mg
2. Domain d6wbsb_: 6wbs B: [402735]
  automated match to d2pzga_
  complexed with atp, mg
Domain for 6ze1:
- Domain d6ze1a_: 6ze1 A: [407576]
  Other proteins in same PDB: d6ze1b1, d6ze1b2
  automated match to d2pzga_
  complexed with atp, edo, gol

Mouse (Mus musculus) [TaxId:10090] [102379] (9 PDB entries)
Uniprot P26361 390-670
1. Domains for 1q3h:
  1. Domain d1q3ha_: 1q3h A: [95688]
    Other proteins in same PDB: d1q3hc2
    complexed with acy, anp, mg
  2. Domain d1q3hb_: 1q3h B: [95689]
    Other proteins in same PDB: d1q3hc2
    complexed with acy, anp, mg
  3. Domain d1q3hc1: 1q3h C:389-670 [95690]
    Other proteins in same PDB: d1q3hc2
    complexed with acy, anp, mg
  4. Domain d1q3hd_: 1q3h D: [95691]
    Other proteins in same PDB: d1q3hc2
    complexed with acy, anp, mg
2. Domains for 1r0w:
  1. Domain d1r0wa_: 1r0w A: [96754]
    Other proteins in same PDB: d1r0wc2
    complexed with acy
  2. Domain d1r0wb_: 1r0w B: [96755]
    Other proteins in same PDB: d1r0wc2
    complexed with acy
  3. Domain d1r0wc1: 1r0w C:389-670 [96756]
    Other proteins in same PDB: d1r0wc2
    complexed with acy
  4. Domain d1r0wd_: 1r0w D: [96757]
    Other proteins in same PDB: d1r0wc2
    complexed with acy
3. Domains for 1r0x:
  1. Domain d1r0xa_: 1r0x A: [96758]
    Other proteins in same PDB: d1r0xc2
    complexed with acy, atp, mg
  2. Domain d1r0xb_: 1r0x B: [96759]
    Other proteins in same PDB: d1r0xc2
    complexed with acy, atp, mg
  3. Domain d1r0xc1: 1r0x C:389-670 [96760]
    Other proteins in same PDB: d1r0xc2
    complexed with acy, atp, mg
  4. Domain d1r0xd_: 1r0x D: [96761]
    Other proteins in same PDB: d1r0xc2
    complexed with acy, atp, mg
4. Domains for 1r0y:
  1. Domain d1r0ya_: 1r0y A: [96762]
    Other proteins in same PDB: d1r0yc2
    complexed with acy, adp
  2. Domain d1r0yb_: 1r0y B: [96763]
    Other proteins in same PDB: d1r0yc2
    complexed with acy, adp
  3. Domain d1r0yc1: 1r0y C:389-670 [96764]
    Other proteins in same PDB: d1r0yc2
    complexed with acy, adp
  4. Domain d1r0yd_: 1r0y D: [96765]
    Other proteins in same PDB: d1r0yc2
    complexed with acy, adp
5. Domains for 1r0z:
  1. Domain d1r0za_: 1r0z A: [96766]
    Other proteins in same PDB: d1r0zc2
    complexed with acy, atp, mg
  2. Domain d1r0zb_: 1r0z B: [96767]
    Other proteins in same PDB: d1r0zc2
    complexed with acy, atp, mg
  3. Domain d1r0zc1: 1r0z C:389-670 [96768]
    Other proteins in same PDB: d1r0zc2
    complexed with acy, atp, mg
  4. Domain d1r0zd_: 1r0z D: [96769]
    Other proteins in same PDB: d1r0zc2
    complexed with acy, atp, mg
6. Domains for 1r10:
  1. Domain d1r10a_: 1r10 A: [96770]
    complexed with acy, atp, mg
  2. Domain d1r10b_: 1r10 B: [96771]
    complexed with acy, atp, mg
7. Domains for 1xf9:
  1. Domain d1xf9a_: 1xf9 A: [115245]
    Other proteins in same PDB: d1xf9c2
    complexed with acy, atp, mg; mutant
  2. Domain d1xf9b_: 1xf9 B: [115246]
    Other proteins in same PDB: d1xf9c2
    complexed with acy, atp, mg; mutant
  3. Domain d1xf9c1: 1xf9 C:389-670 [115247]
    Other proteins in same PDB: d1xf9c2
    complexed with acy, atp, mg; mutant
  4. Domain d1xf9d_: 1xf9 D: [115248]
    Other proteins in same PDB: d1xf9c2
    complexed with acy, atp, mg; mutant
8. Domains for 1xfa:
  1. Domain d1xfaa_: 1xfa A: [115249]
    complexed with acy, atp, cl, mg; mutant
  2. Domain d1xfab_: 1xfa B: [115250]
    complexed with acy, atp, cl, mg; mutant
9. Domains for 3si7:
  1. Domain d3si7a_: 3si7 A: [185410]
    Other proteins in same PDB: d3si7c2
    automated match to d1q3hc_
    complexed with act, atp, mg; mutant
  2. Domain d3si7b_: 3si7 B: [185411]
    Other proteins in same PDB: d3si7c2
    automated match to d1q3hc_
    complexed with act, atp, mg; mutant
  3. Domain d3si7c1: 3si7 C:389-670 [185412]
    Other proteins in same PDB: d3si7c2
    automated match to d1q3hc_
    complexed with act, atp, mg; mutant
  4. Domain d3si7d_: 3si7 D: [185413]
    Other proteins in same PDB: d3si7c2
    automated match to d1q3hc_
    complexed with act, atp, mg; mutant

More info for Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like

Timeline for Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like:

Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like first appeared in SCOP 1.67
Protein Cystic fibrosis transmembrane conductance regulator, CFTR, nucleotide-binding domain from c.37.1.12: ABC transporter ATPase domain-like appears in SCOPe 2.07