Lineage for Superfamily c.8.8: Putative cyclase

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.8: The "swivelling" beta/beta/alpha domain [52008] (9 superfamilies) 3 layers: b/b/a; the central sheet is parallel, and the other one is antiparallel; there are some variations in topology this domain is thought to be mobile in most multi-domain proteins known to contain it

4. Superfamily c.8.8: Putative cyclase [102198] (1 family) contains mixed beta-sheet barrel, closed n=7, S=10