SCOP 1.71: Protein: Hydroxyisobutyrate dehydrogenase

Lineage for Protein: Hydroxyisobutyrate dehydrogenase

Root: SCOP 1.71
Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (15 proteins)
the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
C-terminal domains also show some similarity

Protein Hydroxyisobutyrate dehydrogenase [102171] (2 species)

Species:

Salmonella typhimurium [TaxId:90371] [110431] (1 PDB entry)
- Domain for 1vpd:
  - Domain d1vpda2: 1vpd A:3-163 [113952]
    Other proteins in same PDB: d1vpda1
    Structural genomics target
    complexed with cl, tla
Thermus thermophilus [TaxId:274] [102172] (1 PDB entry)
- Domains for 1j3v:
  1. Domain d1j3va2: 1j3v A:2-157 [90826]
    Other proteins in same PDB: d1j3va1, d1j3vb1, d1j3vc1, d1j3vd1
  2. Domain d1j3vb2: 1j3v B:2-157 [90828]
    Other proteins in same PDB: d1j3va1, d1j3vb1, d1j3vc1, d1j3vd1
  3. Domain d1j3vc2: 1j3v C:1-157 [90830]
    Other proteins in same PDB: d1j3va1, d1j3vb1, d1j3vc1, d1j3vd1
  4. Domain d1j3vd2: 1j3v D:2-157 [90832]
    Other proteins in same PDB: d1j3va1, d1j3vb1, d1j3vc1, d1j3vd1
    structural genomics
    complexed with ndp

More info for Protein Hydroxyisobutyrate dehydrogenase from c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain

Timeline for Protein Hydroxyisobutyrate dehydrogenase from c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain:

Protein Hydroxyisobutyrate dehydrogenase from c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain first appeared in SCOP 1.67
Protein Hydroxyisobutyrate dehydrogenase from c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain appears in SCOP 1.69
Protein Hydroxyisobutyrate dehydrogenase from c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain appears in SCOP 1.73
Protein Hydroxyisobutyrate dehydrogenase from c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain appears in the current release, SCOPe 2.08