SCOPe 2.04: Protein: Hydroxyisobutyrate dehydrogenase

Lineage for Protein: Hydroxyisobutyrate dehydrogenase

Root: SCOPe 2.04
Class a: All alpha proteins [46456] (285 folds)

Fold a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (13 families)
N-terminal domain is Rossmann-fold with a family-specific C-terminal extension

Family a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain [48180] (3 proteins)
Hydroxyisobutyrate dehydrogenase domain is similar to one structural repeat in the 6-phosphogluconate dehydrogenase domain

Protein Hydroxyisobutyrate dehydrogenase [101357] (3 species)
forms similar dimeric and tetrameric structures to the 6-phosphogluconate dehydrogenase domain and its dimer, respectively

Species:

Pseudomonas aeruginosa [TaxId:287] [158733] (2 PDB entries)
Uniprot Q9I5I6 163-296
1. Domain for 3obb:
  - Domain d3obba1: 3obb A:163-296 [182914]
    Other proteins in same PDB: d3obba2
    complexed with act, edo, epe
2. Domain for 3q3c:
  - Domain d3q3ca2: 3q3c A:163-296 [233311]
    Other proteins in same PDB: d3q3ca1
    automated match to d3obba1
    complexed with nad
Salmonella typhimurium [TaxId:90371] [109948] (1 PDB entry)
Uniprot Q8ZLV8
- Domain for 1vpd:
  - Domain d1vpda1: 1vpd A:164-296 [113951]
    Other proteins in same PDB: d1vpda2
    Structural genomics target
    complexed with cl, tla
Thermus thermophilus [TaxId:274] [101358] (2 PDB entries)
structural genomics
1. Domains for 1wp4:
  1. Domain d1wp4a1: 1wp4 A:158-289 [121135]
    Other proteins in same PDB: d1wp4a2, d1wp4b2, d1wp4c2, d1wp4d2
    automatically matched to d1j3va1
    complexed with ndp, so4
  2. Domain d1wp4b1: 1wp4 B:158-289 [121137]
    Other proteins in same PDB: d1wp4a2, d1wp4b2, d1wp4c2, d1wp4d2
    automatically matched to d1j3va1
    complexed with ndp, so4
  3. Domain d1wp4c1: 1wp4 C:158-289 [121139]
    Other proteins in same PDB: d1wp4a2, d1wp4b2, d1wp4c2, d1wp4d2
    automatically matched to d1j3va1
    complexed with ndp, so4
  4. Domain d1wp4d1: 1wp4 D:158-289 [121141]
    Other proteins in same PDB: d1wp4a2, d1wp4b2, d1wp4c2, d1wp4d2
    automatically matched to d1j3va1
    complexed with ndp, so4
2. Domains for 2cvz:
  1. Domain d2cvza1: 2cvz A:158-289 [130890]
    Other proteins in same PDB: d2cvza2, d2cvzb2, d2cvzc2, d2cvzd2
    automatically matched to d1j3va1
    complexed with ndp
  2. Domain d2cvzb1: 2cvz B:158-289 [130892]
    Other proteins in same PDB: d2cvza2, d2cvzb2, d2cvzc2, d2cvzd2
    automatically matched to d1j3va1
    complexed with ndp
  3. Domain d2cvzc1: 2cvz C:158-289 [130894]
    Other proteins in same PDB: d2cvza2, d2cvzb2, d2cvzc2, d2cvzd2
    automatically matched to d1j3va1
    complexed with ndp
  4. Domain d2cvzd1: 2cvz D:158-289 [130896]
    Other proteins in same PDB: d2cvza2, d2cvzb2, d2cvzc2, d2cvzd2
    automatically matched to d1j3va1
    complexed with ndp

More info for Protein Hydroxyisobutyrate dehydrogenase from a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain

Timeline for Protein Hydroxyisobutyrate dehydrogenase from a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain:

Protein Hydroxyisobutyrate dehydrogenase from a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain first appeared in SCOP 1.67
Protein Hydroxyisobutyrate dehydrogenase from a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain appears in SCOPe 2.03
Protein Hydroxyisobutyrate dehydrogenase from a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain appears in SCOPe 2.05
Protein Hydroxyisobutyrate dehydrogenase from a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain appears in the current release, SCOPe 2.08