SCOP 1.75: Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain

Lineage for Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain

1. Root: SCOP 1.75

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain [100888] (4 proteins)
   contains a distinct 'fingers' domain possibly related to the C-terminal subdomain of hypothetical protein Ta1206 (1qw2)

Proteins:

1. DinB homolog (DBH) [100889] (3 species)

   1. Species Archaeon Sulfolobus solfataricus [TaxId:2287] [100891] (3 PDB entries)

   2. Species Archaeon Sulfolobus solfataricus, DNA polymerase IV [TaxId:2287] [100890] (50 PDB entries)

   3. Species Sulfolobus acidocaldarius Brock et al. 1972 (Sulfolobus acidocaldarius) [TaxId:2285] [160954] (3 PDB entries)

2. DNA polymerase eta [100892] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [100893] (3 PDB entries)

3. DNA polymerase iota [111295] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [111296] (8 PDB entries)
     Uniprot Q9UNA4

4. DNA polymerase kappa [111297] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [111298] (1 PDB entry)
     Uniprot Q9UBT6 71-517

More info for Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain

Timeline for Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain:

• Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain first appeared in SCOP 1.67
  
• Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain appears in SCOP 1.73
  
• Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain appears in SCOPe 2.01
  
• Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain appears in the current release, SCOPe 2.08