SCOPe 2.01: Domain d1uwja_: 1uwj A:

Lineage for d1uwja_ (1uwj A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein B-Raf kinase [103290] (1 species)
   OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

7. Species Human (Homo sapiens) [TaxId:9606] [103291] (2 PDB entries)

8. Domain d1uwja_: 1uwj A: [100125]
   complexed with bax; mutant

Details for d1uwja_

PDB Entry: 1uwj, 3.5 Å

PDB Description: the complex of mutant v599e b-raf and bay439006.

PDB Compounds: (A:) B-Raf proto-oncogene serine/threonine-protein kinase

SCOPe Domain Sequences for d1uwja_:

Sequence, based on SEQRES records:

>d1uwja_ d.144.1.7 (A:) B-Raf kinase {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglateksrwsgshqfeqlsgsilwmapevirm
qdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpk
amkrlmaeclkkkrderplfpqilasiellarslpk

Sequence, based on observed residues (ATOM records):

>d1uwja_ d.144.1.7 (A:) B-Raf kinase {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglateksgsilwmapevirmqdknpysfqsdv
yafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkk
krderplfpqilasiellarslpk

Timeline for d1uwja_:

• d1uwja_ first appeared in SCOP 1.67
  
• d1uwja_ appears in SCOP 1.75
  
• d1uwja_ appears in SCOPe 2.02
  
• d1uwja_ appears in the current release, SCOPe 2.08