SCOP 1.71: Domain d1uwhb_: 1uwh B:

Lineage for d1uwhb_ (1uwh B:)

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (60 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein B-Raf kinase [103290] (1 species)
   OPK group; RAF subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

7. Species Human (Homo sapiens) [TaxId:9606] [103291] (2 PDB entries)

8. Domain d1uwhb_: 1uwh B: [100124]
   complexed with bax, cl

Details for d1uwhb_

PDB Entry: 1uwh, 2.95 Å

PDB Description: the complex of wild type b-raf and bay439006.

SCOP Domain Sequences for d1uwhb_:

Sequence, based on SEQRES records:

>d1uwhb_ d.144.1.7 (B:) B-Raf kinase {Human (Homo sapiens)}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystapqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevirm
qdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpk
amkrlmaeclkkkrderplfpqilasiellarslpk

Sequence, based on observed residues (ATOM records):

>d1uwhb_ d.144.1.7 (B:) B-Raf kinase {Human (Homo sapiens)}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystapqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdyl
haksiihrdlksnniflhedltvkigdfglatvlsgsilwmapevirmqdknpysfqsdv
yafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkk
krderplfpqilasiellarslpk

Timeline for d1uwhb_:

• d1uwhb_ first appeared in SCOP 1.67
  
• d1uwhb_ appears in SCOP 1.69
  
• d1uwhb_ appears in SCOP 1.73
  
• d1uwhb_ appears in the current release, SCOPe 2.08