Lineage for d5hx8a_ (5hx8 A:)

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 2979545Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2979546Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2984752Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2984753Protein automated matches [190417] (36 species)
    not a true protein
  7. 2984910Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)
  8. 2986255Domain d5hx8a_: 5hx8 A: [315075]
    automated match to d4ehza_
    complexed with 66p

Details for d5hx8a_

PDB Entry: 5hx8 (more details), 2.2 Å

PDB Description: jak1 complex with 4-[(4-aminocyclohexyl)amino]-3-(1h-benzimidazol-2- yl)-1h-pyridin-2-one
PDB Compounds: (A:) Tyrosine-protein kinase JAK1

SCOPe Domain Sequences for d5hx8a_:

Sequence, based on SEQRES records: (download)

>d5hx8a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpes
ggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknknk
inlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkey
ytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigp
thgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

Sequence, based on observed residues (ATOM records): (download)

>d5hx8a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpnh
iadlkkeieilrnlyhenivkykgictengiklimeflpsgslkeylpknknkinlkqql
kyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddr
dspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtv
trlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

SCOPe Domain Coordinates for d5hx8a_:

Click to download the PDB-style file with coordinates for d5hx8a_.
(The format of our PDB-style files is described here.)

Timeline for d5hx8a_: