Lineage for d4i6ha_ (4i6h A:)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2218047Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2218048Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2222093Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2222094Protein automated matches [190417] (25 species)
    not a true protein
  7. 2222237Species Human (Homo sapiens) [TaxId:9606] [187294] (882 PDB entries)
  8. 2222755Domain d4i6ha_: 4i6h A: [222957]
    automated match to d3uytb_
    complexed with 1c8

Details for d4i6ha_

PDB Entry: 4i6h (more details), 1.91 Å

PDB Description: Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce alpha-Synuclein Phosphorylation in Rat Brain
PDB Compounds: (A:) Serine/threonine-protein kinase PLK2

SCOPe Domain Sequences for d4i6ha_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4i6ha_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
riivdpttgkrysrgktlgkggfakcyemtdltnnkvyaakiiphsrvskphqrekidke
ielhrilhhkhvvqfyhyfedkeniyilleycsrrsmahilkarkvltepevryylrqiv
sglkylheqeilhrdlklgnffinesmelkvgdfglaarleplehrrrticgtpnylspe
vlnkqghgaesdiwalgcvmytmllgrppfettnlketyrsirearytmpssllapakhl
iasmlsknpedrpslddiirhdfftqgftpdrlssscchtvpdfh

SCOPe Domain Coordinates for d4i6ha_:

Click to download the PDB-style file with coordinates for d4i6ha_.
(The format of our PDB-style files is described here.)

Timeline for d4i6ha_: