Lineage for d3ui7a_ (3ui7 A:)

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2349642Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  4. 2349643Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families) (S)
  5. 2350180Family a.211.1.0: automated matches [191566] (1 protein)
    not a true family
  6. 2350181Protein automated matches [190983] (10 species)
    not a true protein
  7. 2350200Species Human (Homo sapiens) [TaxId:9606] [188676] (136 PDB entries)
  8. 2350337Domain d3ui7a_: 3ui7 A: [233789]
    automated match to d3wi2a_
    complexed with c1l, mg, zn

Details for d3ui7a_

PDB Entry: 3ui7 (more details), 2.28 Å

PDB Description: Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia
PDB Compounds: (A:) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

SCOPe Domain Sequences for d3ui7a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3ui7a_ a.211.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
wqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfeleklcrfimsv
kknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhrgfsnsyl
qkfdhplaalyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaiiatdl
alyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtkltandiyae
fwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilpptepllkac
rdnlsqwekvirgee

SCOPe Domain Coordinates for d3ui7a_:

Click to download the PDB-style file with coordinates for d3ui7a_.
(The format of our PDB-style files is described here.)

Timeline for d3ui7a_: