Lineage for d1umdb1 (1umd B:2-187)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2864564Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2864565Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2864755Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 proteins)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
    automatically mapped to Pfam PF02779
  6. 2864759Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species)
  7. 2864784Species Thermus thermophilus [TaxId:274] [102332] (4 PDB entries)
  8. 2864785Domain d1umdb1: 1umd B:2-187 [99600]
    Other proteins in same PDB: d1umda_, d1umdb2, d1umdc_, d1umdd2
    complexed with coi, mg, tdp

Details for d1umdb1

PDB Entry: 1umd (more details), 1.9 Å

PDB Description: branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate
PDB Compounds: (B:) 2-oxo acid dehydrogenase beta subunit

SCOPe Domain Sequences for d1umdb1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1umdb1 c.36.1.7 (B:2-187) Branched-chain alpha-keto acid dehydrogenase, Pyr module {Thermus thermophilus [TaxId: 274]}
almtmvqalnraldeemakdprvvvlgedvgkrggvflvtegllqkygpdrvmdtplsea
aivgaalgmaahglrpvaeiqfadyifpgfdqlvsqvaklryrsggqftaplvvrmpsgg
gvrgghhhsqspeahfvhtaglkvvavstpydakgllkaairdedpvvflepkrlyrsvk
eevpee

SCOPe Domain Coordinates for d1umdb1:

Click to download the PDB-style file with coordinates for d1umdb1.
(The format of our PDB-style files is described here.)

Timeline for d1umdb1:

2864785
d1umdb1 in context of chain
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Domains from same chain:
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d1umdb2