Lineage for d1tt5a_ (1tt5 A:)

  1. Root: SCOPe 2.03
  2. 1336837Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1394913Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
  4. 1394914Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families) (S)
    transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
    the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
  5. 1394921Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins)
    the common fold is elaborated with additional (sub)domains
  6. 1394922Protein Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
    a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion
  7. 1394923Species Human (Homo sapiens) [TaxId:9606] [89767] (8 PDB entries)
    Uniprot Q13564
  8. 1394926Domain d1tt5a_: 1tt5 A: [107291]
    Other proteins in same PDB: d1tt5b_, d1tt5d_
    complexed with zn

Details for d1tt5a_

PDB Entry: 1tt5 (more details), 2.6 Å

PDB Description: structure of appbp1-uba3-ubc12n26: a unique e1-e2 interaction required for optimal conjugation of the ubiquitin-like protein nedd8
PDB Compounds: (A:) amyloid protein-binding protein 1

SCOPe Domain Sequences for d1tt5a_:

Sequence, based on SEQRES records: (download)

>d1tt5a_ c.111.1.2 (A:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens) [TaxId: 9606]}
maqlgkllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftii
dgnqvsgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsff
crftvvvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnal
edlrldkpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktykek
edfrdlirqgilkpedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfw
ilaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakll
qsigqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivl
ylmlravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcry
gaaephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

Sequence, based on observed residues (ATOM records): (download)

>d1tt5a_ c.111.1.2 (A:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens) [TaxId: 9606]}
maqlgkllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftii
dgnqvsgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsff
crftvvvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnal
edlrldkpfpelrehfqsyddhshtpwiviiakylaqwysetngripktykekedfrdli
rqgilkpedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwilaralk
efvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigqap
esisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylmlrav
drfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaaepht
iaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

SCOPe Domain Coordinates for d1tt5a_:

Click to download the PDB-style file with coordinates for d1tt5a_.
(The format of our PDB-style files is described here.)

Timeline for d1tt5a_: