Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module [88749] (8 proteins) the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology |
Protein Pyruvate decarboxylase [88750] (3 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88752] (2 PDB entries) |
Domain d1qpba3: 1qpb A:361-556 [31782] Other proteins in same PDB: d1qpba1, d1qpba2, d1qpbb1, d1qpbb2 complexed with mg, pym, tpp |
PDB Entry: 1qpb (more details), 2.4 Å
SCOPe Domain Sequences for d1qpba3:
Sequence; same for both SEQRES and ATOM records: (download)
>d1qpba3 c.36.1.9 (A:361-556) Pyruvate decarboxylase {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]} astplkqewmwnqlgnflqegdvviaetgtsafginqttfpnntygisqvlwgsigfttg atlgaafaaeeidpkkrvilfigdgslqltvqeistmirwglkpylfvlnndgytiekli hgpkaqyneiqgwdhlsllptfgakdyethrvattgewdkltqdksfndnskirmievml pvfdapqnlveqaklt
Timeline for d1qpba3: