PDB entry 8grg

View 8grg on RCSB PDB site
Description: Crystal structure of a constitutively active mutant of the alpha gamma heterodimer of human IDH3
Class: oxidoreductase
Keywords: Isocitrate dehydrogenase, IDH3, NAD-dependent IDH, assembly, allosteric regulation, OXIDOREDUCTASE
Deposited on 2022-09-01, released 2022-11-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-12-21, with a file datestamp of 2022-12-16.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Human IDH3 alpha subunit
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P50213 (0-338)
      • engineered mutation (138)
    Domains in SCOPe 2.08: d8grga_
  • Chain 'B':
    Compound: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH3G
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8grgb_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >8grgA (A:)
tggvqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqgpggkwmipseakes
mdknkmglkgplktpiaaghpsmnlllrktfdlyanvrpcvsiegyktpytdvnivtire
ntegeysgiehvivdgvvasiklitegaskriaefafeyarnnhrsnvtavhkanimrms
dglflqkcrevaesckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagli
gglgvtpsgnigangvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaari
eaacfatikdgksltkdlggnakcsdfteeicrrvkdld

    Sequence, based on observed residues (ATOM records): (download) 
    >8grgA (A:)
vqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqwmipseakesmdknkmgl
kgplktpsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirentegeysgiehviv
dgvvasiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdglflqkcrevaes
ckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagligglgvtpsgnigan
gvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaarieaacfatikdgksl
tkdlggnakcsdfteeicrrvkdl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >8grgB (B:)
fseqtippsakyggrhtvtmipgdgigpelmlhvksvfrhacvpvdfeevhvssnadeed
irnaimairrnrvalkgnietnhnlppshksrnnilrtsldlyanvihckslpgvvtrhk
didilivrentegeysslehesvagvveslkiitkakslriaeyafklaqesgrkkvtav
hkanimklgdglflqccrevaarypqitfenmivdnttmqlvsrpqqfdvmvmpnlygni
vnnvcaglvggpglvaganyghvyavfetatrntgksianknianptatllascmmldhl
klhsyatsirkavlasmdnenmhtpdiggqgttseaiqdvirhirvingravea

    Sequence, based on observed residues (ATOM records): (download) 
    >8grgB (B:)
rhtvtmipgdgigpelmlhvksvfrhacvpvdfeevhedirnaimairrnrvalkgniek
srnnilrtsldlyanvihckslpgvvtrhkdidilivrenslehesvagvveslkiitka
kslriaeyafklaqesgrkkvtavhkanimklgdglflqccrevaarypqitfenmivdn
ttmqlvsrpqqfdvmvmpnlygnivnnvcaglvggpglvaganyghvyavfetatrntgk
sianknianptatllascmmldhlklhsyatsirkavlasmdnenmhtpdiggqgttsea
iqdvirhirvingravea