PDB entry 8czv

View 8czv on RCSB PDB site
Description: Structure of MERS 3CL protease in complex with the cyclopropane based inhibitor 17d
Class: hydrolase/hydrolase inhibitor
Keywords: PROTEASE, severe acute respiratory syndrome coronavirus 2, MERS 3CL protease Inhhibitors, hydrolase, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2022-05-25, released 2022-06-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-08-03, with a file datestamp of 2022-07-29.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3C-like proteinase
    Species: Middle East respiratory syndrome-related coronavirus [TaxId:1335626]
    Gene: ORF1a
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8czva1, d8czva2
  • Heterogens: P8C, PJR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >8czvA (A:)
mhhhhhhsglvkmshpsgdveacmvqvtcgsmtlnglwldntvwcprhvmcpadqlsdpn
ydallismtnhsfsvqkhigapanlrvvghamqgtllkltvdvanpstpaytfttvkpga
afsvlacyngrptgtftvvmrpnytikgsflcgscgsvgytkegsvinfcymhqmelang
thtgsafdgtmygafmdkqvhqvqltdkycsvnvvawlyaailngcawfvkpnrtsvvsf
newalanqftefvgtqsvdmlavktgvaieqllyaiqqlytgfqgkqilgstmledeftp
edvnmqimgvvmq

    Sequence, based on observed residues (ATOM records): (download) 
    >8czvA (A:)
hhsglvkmshpsgdveacmvqvtcgsmtlnglwldntvwcprhvmcpadqlsdpnydall
ismtnhsfsvqkhanlrvvghamqgtllkltvdvanpstpaytfttvkpgaafsvlacyn
grptgtftvvmrpnytikgsflcgscgsvgytkegsvinfcymhqmelangthtgsafdg
tmygafmdkqvhqvqltdkycsvnvvawlyaailngcawfvkpnrtsvvsfnewalanqf
tefvgtqsvdmlavktgvaieqllyaiqqlytgfqgkqilgstmledeftpedvnmqimg
vvm